Preparation and physicochemical characterization of topical quercetin loaded liposome

Authors

  • Neda Bavarsad Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Golnaz Hemmati Student Research Committee, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Shirin Ataee Student Research Committee, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Neda Sistani Karampour Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

DOI:

https://doi.org/10.30827/ars.v60i1.8201

Keywords:

Quercetin, Liposome, Fusion, Topical

Abstract

Background: The use of herbal extracts in recent years has been of great interest to researchers around the world. Quercetin antoxidant properties play an important role in various fields of health.

Objective: Due to the low skin permeability and poor solubility in aqua media, quercetin liposome formulation has been used to obtain topical use of this substance.

Methods: In this study, liposomal quercetin was prepared by fusion method and the physicochemical characteristics of the formulation, including particle size, incorporation efficiency and in vitro drug release were evaluated.

Results: The particle size of formulations were between 7.68 to 58.1 nm. The incorporation efficiency of formulations were in range of 80.55 to 96.80 percent. In vitro drug release of formulations were about 60 to 70 percent.

Conclusion: According to the results obtained, it can be said that the use of this substance as a liposomal formulation can improve physicochemical properties of the drug in the laboratory conditions and provide it as a suitable candidate for further in vivo and clinical studies.

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Published

2019-03-20

How to Cite

1.
Bavarsad N, Hemmati G, Ataee S, Sistani Karampour N. Preparation and physicochemical characterization of topical quercetin loaded liposome. Ars Pharm [Internet]. 2019 Mar. 20 [cited 2024 Jul. 22];60(1):41-6. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/8201

Issue

Vol. 60 No. 1 (2019)

Section

Original Articles

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Copyright (c) 2019 Neda Bavarsad, Golnaz Hemmati, Shirin Ataee, Neda Sistani Karampour

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