Evaluation of dimethylsulfoxide and Aloe vera as penetration enhancers for cutaneous application of lidocaine
DOI:
https://doi.org/10.30827/ars.v60i2.8084Keywords:
Lidocaine, Aloe vera, Carbopol 934, dimetilsulfoxidoAbstract
Objective: The objective of the present work was to compare and verify efficacy of Aloe vera (1 to 3 %) with dimethyl sulfoxide (1 to 3 %) for its penetration enhancing property for topical delivery of lidocaine.
Method: Carbopol 934 was used as gelling agent for preparation of lidocaine gel formulations containing or not dimetilsulfoxido or Aloe vera (1%, 2% and 3%). Gels were evaluated for physical appearance, rheological behavior, drug content, drug release and stability.
Results: It was inferred from result that obtained gel formulation were good in appearance, homogeneity and consistency. In vitro drug release profiles showed that concentrations of Aloe vera gel increased in formulations, the drug release rate increased substantially. It was observed that F6 formulation which comprised of 3% Aloe vera as permeation enhancer exhibited 79.18 % of drug release. Similarly, for formulation F3 which comprised of 3% dimetilsulfoxido as permeation enhancer the drug release was found to be 84.52%. Use of Aloe vera may prove to be beneficial as compared to synthetic permeation enhancers.
Conclusion: Based on results of the study it was concluded that the topical gel of lidocaine prepared along with Carbopol 934 by using Aloe vera as a natural penetration enhancer at a concentration of 3% can be used to enhance the penetration for lidocain across the skin.
Downloads
References
Patil S, Adnaik R, Bhutkar MA, Mohite SK. Formulation and evaluation microemulsion based gel. Int J Uni Pharm Biosci. 2014;3(4):423-435.
Kamble A, Adnaik R, Bhutkar MA. Formulation and evaluation of Itraconazole emulgel for topical drug delivery. Int J Uni Pharm Biosci. 2014;3(5):37-45.
Patil BS, Tanushree S, Tina R, Bhutkar MA, Mohite SK. Formulation and evaluation of transdermal patches of Baclofen. Asian J Pharm Res Develop. 2014;2(5):16-25.
Ogle OE, Mahjoubi G. Local anesthesia: agents, techniques, and complications. Dental Cli North Am. 2012;56(1):133–148. Doi: 10.1016/j.cden.2011.08.003.
Som I, Bhatia K, Mohd. Yasir M. Status of surfactants as penetration enhancers in transdermal drug delivery. J Pharm Bioallied Sci. 2012;4(1):2–9. Doi: 10.4103/0975-7406.92724.
Barry BW. Mode of action of penetration enhancers in human skin. J Control Release. 1987;6:85-97. Doi:10.1016/0168-3659(87)90066-6.
Mutimer MN, Riffikin C, Hill JA, Marry E, Glickman CN. Synthesis of methylsilyl derivates of procaine and their diffusion. J Am Pharm Assoc Sci. 1956;.45:212-8.
Sharma K, Mittal A, Sheikh M, Agrahari P. Investigating the potential of Aloe vera as penetration enhancer for transdermal delivery. Int Bull Drug Res. 2015;5(8):41-50.
Marren K. Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs. Physician Sports Med. 2011;39(3):75-82. Doi: 10.3810/psm.2011.09.1923.
Davis J, Rowley S, Braine H, Piantadosi S, Santos G. Clinical toxicity of cryopreserved bone marrow graft infusion. Blood. 1990;75:781–786.
Swanson B. Medical use of Dimethyl sulfoxide (DMSO). Rev Clin Basic Pharmacol. 1985; 5:1–33.
Cavaletti G, Oggioni N, Sala F, Pezzoni G, Cavalletti E, Marmiroli P, Petruccioli MG, Frattola L, Tredici G. Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study. Toxico Let. 2000;118:103–107.
Franco R, Weiner M, Wagner K, Martelo O. Incorporation of inositol hexaphosphate into red blood cells mediated by dimethyl sulfoxide. Life Science. 1983;32:2763–2768.
Scala K, Antonio V, Kong A. Chemical and physical properties of Aloe vera (Aloe barbadensis Miller) gel stored after high hydrostatic pressure processing. J Food Sci Tech. 2013;33(1):52-59. Doi: 10.1590/S0101-20612013005000002.
Rajeswari R, Umadevi M, Rahale S, Pushpa R, Selvavenkadesh S, Sampath Kumar KP, Bhowmi D. Aloe vera: The miracle plant its medicinal and traditional uses in India. J Pharmacog Phytochem. 2012;1(4):118-124.
Munoz OM, Leal X, Quitral V, Cardemil L. Extraction, characterization and properties of the gel of Aloe vera (Aloe barbadensis Miller) Cultivated in Chile. Med Aromat Plants. 2015;4(3):2-7. Doi:10.4172/2167-0412.1000199.
Mulik M, Phale M. Extraction, purification and identification of aloe gel from Aloe vera (Aloe barbadensis Miller). J Nat Prod. 2009;5(3):111-115.
Background review for sodium laurylsulfate used as an excipient, EMA/CHMP/351898/2014, Published on 23rd July 2015. https://www.ema.europa.eu/en/documents/report/background-review-sodium-laurilsulfate-used-excipient-context-revision-guideline-excipients-label_en.pdf assessed on 15th Dec 2017.
Bhinge SD, Bhutkar MA, Randive DS, Wadkar GH, Todkar SS, Kakade MP, Kadam MP. Formulation development and evaluation of antimicrobial polyherbal gel. Ann Pharm Fr. 2017;75(5):349-358. Doi: 10.1016/j.pharma.2017.04.006.
Bhinge SD, Bhutkar MA, Randive DS, Wadkar GH, Kamble SY, Kalel PD, Kadam SS. Formulation and evaluation of polyherbal gel containing extracts of Azadirachta indica, Adhatoda vasica, Piper betle, Ocimum tenuiflorum and Pongamia pinnata. J Res Pharm. 2019;23(1):44-54. Doi:10.12991/jrp.2018.107.
Marwa HS, Ghada FM. Evaluation of Topical Gel Bases Formulated with Various Essential Oils for Antibacterial Activity against Methicillin Resistant Staphylococcus Aureus. Trop J Pharm Res 2013;12(6):877-884. Doi:10.4314/tjpr.v12i6.3.
Sera UV, Ramana MV. In vitro skin absorption and drug release – a comparison of four commercial hydrophilic gel preparations for topical use. The Indian Pharmacist 2006;73:356-360.
Singh J, Tripathi KP, Sakia TR. Effect of penetration enhancers on the in vitro transport of ephedrine through rat skin and human epidermis from matrix based transdermal formulations. Drug Dev Ind Pharm. 1993;19:1623-8. Doi:10.3109/03639049309069331.
Abou el Ela AEF, Ibrahim EH, Allam AA. Bucco-adhesive tablets containing metoprololtartarate: formulation, in vitro and in vivo characterization. J Drug Deliv Sci Tech. 2013;23:171–179. Doi: 10.1016/S1773-2247(13)50026-8.
Kiran S, Ashu M, Priyanka A. Skin permeation of Candesartan Cilexetil from transdermal patch containing Aloe Vera gel as penetration enhancer. Asian J Pharm. 2016;10 (2):31-43. Doi: 10.22377/ajp.v10i2.611.
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Somnath Devidas Bhinge, Mangesh Anil Bhutkar, Dheeraj S Randive, Omprasad Nayakal, Prajakta Patil
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:
- The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.
b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.
c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).
