Caracterización y estudio de solubilidad de mezclas binarias de flunarizina / polietilenglicol 4000
Keywords:
Flunarizina, Polietilenglicol 4000, Dispersiones sólidas, SolubilidadAbstract
En este trabajo estudiamos las interacciones de la flunarizina con polietilenglicol 4000 en dispersiones sólidas preparadassiguiendo el método de disolución propuesto por Sekiguchi y Obi. Como elementos de comparación se hanutilizado mezclas físicas de ambos componentes, preparados en las mismas proporciones de fármaco/polímero: 10/90, 20/80, 30/70, 40/60, 50/50,60/40 y 80/20.Las propiedades fisicoquímicas de las dispersiones sólidas y mezclas físicas se investigan mediante espectroscopíainfrarroja,difracción de rayos X, calorimetría diferencial de barrido y solubilidad en equilibrio. Los espectros deinfrarrojo indican que no ha habido interacción química entre la flunarizina y el PEG. Los difractogramas muestranque a determinadas proporciones, el PEG se introduce en la estructura de la flunarizina y los estudios térmicosparecen indicar la formación de una mezcla eutéctica a la proporción 28,96% de flunarizina y 71,04% de PEG 4000.Todas las muestras presentan una solubilidad superior a la del fármaco puro y en ambos tipos de muestras elincremento es mayor al aumentar la proporción de polímero. El análisis de comparación múltiple aplicado independientementea las dispersiones sólidas y mezclas físicas, indica que no existe diferencia estadísticamente significativa(p<0,05) entre las muestras de proporciones 30/70, 40/60, 50/50 y 60/40, pero sí hay diferencias entre éstas y las deproporciones 10/90, 20/80 y 80/20.Downloads
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