Micropartículas de alginato conteniendo paracetamol

Authors

  • AC RODRÍGUEZ-LLIMÓS
  • D CHIAPPETTA
  • ME SZÉLIGA
  • BREGNI C FERNÁNDEZ A Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113) Buenos Aires, Argentina.

Keywords:

Alginato, Emulsificación, Gelificación interna, Micropartículas, Paracetamol

Abstract

Micropartículas conteniendo paracetamol (PCT) han sido obtenidas por emulsificación/gelificación interna de unasolución de alginato dispersada en un aceite vegetal. La morfología y la distribución de tamaño de partícula fuerondeterminadas. Se estudió la concentración de ión calcio resultando ser un parámetro crítico en la producción de lasmicropartículas. Se observó que el incremento en la concentración de calcio produce un aumento en el rendimientototal de micropartículas y en el encapsulación de PCT. La técnica desarrollada permite obtener un sistema concaracterísticas micrométricas óptimas y una mayor eficacia de encapsulación de PCT.

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References

Lamas MC, Bregni C, Frías M, Velázquez R. Hydrogel microspheres for flutamide obtained by múltiple emulsions. S.T.P. Pharma Science 1998; 8(6): 375-378.

Gombotz WR, Wee SF. Protein release from alginate matrices. Advanced Drug Delivery Reviews 1998; 31: 267-285.

Fundueanu G, Esposito E, Mihai D, Carpov A, Desbrieres J, Rinaudo M, Nastruzzi C. Preparation and characterization of Ca-alginate microspheres by a new emulsification method. International Journal of Pharmaceutics 1998; 170: 11-21.

Poncelet D, Lencki R, Beaulieu C, Halle JP, Neufeld RJ, Fournier A. Production of alginate beads by emulsification/internal gelation I. Methodology. Appl. Microbiol. Biotechnol. 1992; 38: 39-45.

Vila Jato JL. Tecnología Farmacéutica – Aspectos fundamentales de los sistemas farmacéuticos y operaciones básicas, Editorial Síntesis, Madrid; 1997, pp. 75-90.

Connors KA, Amidon GL, Stella VJ. Chemical Stability of Pharmaceuticals. 2nd edition. John Wiley & Sons, New York; 1986, pp. 163-168.

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Published

2003-09-20

How to Cite

1.
RODRÍGUEZ-LLIMÓS A, CHIAPPETTA D, SZÉLIGA M, FERNÁNDEZ A BC. Micropartículas de alginato conteniendo paracetamol. Ars Pharm [Internet]. 2003 Sep. 20 [cited 2024 May 18];44(4):333-42. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5672

Issue

Vol. 44 No. 4 (2003)

Section

Original Articles

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