Anti-diarrhoeal properties of Diospyros peregrina in the castor oil-induced diarrhoea model in mice

Authors

  • R ROUF Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208 (Bangladesh)
  • SJ UDDIN Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208 (Bangladesh)
  • JA SHILPI Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208 (Bangladesh)
  • M TOUFIQ-UR-RAHMAN Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD (United Kingdom)
  • MM FERDOUS Department of Botany, University of Rajshahi 6205, Rajshahi (Bangladesh)
  • SD SARKER School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland (United Kingdom)

Keywords:

Diospyros peregrina, Ebenaceae, Diarrhoea, Dysentery, Traditional Medicine

Abstract

Diospyros peregrina Gruke. (Ebenaceae) possesses a number of medicinal properties, and is used in Bangladeshi traditionalmedicine. In this study, the methanol extracts of the barks and seeds of this plant have been investigated inthe castor oil induced diarrhoea model in mice. The extracts were also studied for their anti-bacterial properties bydisc diffusion method against a number of pathogenic bacteria responsible for causing diarrhoea and dysentery. Atthe doses of 250 and 500 mg/kg body weight, the extracts delayed the onset of diarrhoea. The extracts also reduced thefrequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extracts delayedthe intestinal transit of charcoal meal in test animals as compared to the control, and the results were statistically significant. In both cases the seed extract was found to be more potent than the bark extract. The bark extract inhibitedthe growth of Staphylococcus aureus, Shigella dysentery, Escherichia coli and Pseudomonas aeruginosa, whereas theseed extract demonstrated inhibitory activity against S. aureus, S. dysentery and E. coli

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Published

2006-03-20

How to Cite

1.
ROUF R, UDDIN S, SHILPI J, TOUFIQ-UR-RAHMAN M, FERDOUS M, SARKER S. Anti-diarrhoeal properties of Diospyros peregrina in the castor oil-induced diarrhoea model in mice. Ars Pharm [Internet]. 2006 Mar. 20 [cited 2024 May 12];47(1):81-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5018

Issue

Vol. 47 No. 1 (2006)

Section

Original Articles

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