Antidiabetic Activity of Glibenclamide Loaded Liposomes in Alloxan Induced Diabetic Rats

Authors

  • M SINGH Escuela Superior de Ciencias Farmacéuticas Mahatma Gandhi, Área industrial RIICO, Sitapura, Tonk Road, Jaipur-303905 (India).
  • M BALAMURUGAN Escuela Superior de Ciencias Farmacéuticas Mahatma Gandhi, Área industrial RIICO, Sitapura, Tonk Road, Jaipur-303905 (India).
  • A GUPTA Escuela Superior de Farmacia de Jaipur. Área industrial RIICO, Sitapura, Tonk Road, Jaipur-303905 (India)
  • S YADAV Escuela Superior de Ciencias Farmacéuticas Mahatma Gandhi, Área industrial RIICO, Sitapura, Tonk Road, Jaipur-303905 (India).
  • A SHARMA Escuela Superior de Ciencias Farmacéuticas Mahatma Gandhi, Área industrial RIICO, Sitapura, Tonk Road, Jaipur-303905 (India).
  • A ACHARYA Escuela Superior de Ciencias Farmacéuticas Mahatma Gandhi, Área industrial RIICO, Sitapura, Tonk Road, Jaipur-303905 (India).
  • M RAMASAMY Escuela Superior de Ciencias Farmacéuticas Mahatma Gandhi, Área industrial RIICO, Sitapura, Tonk Road, Jaipur-303905 (India).

Keywords:

Anti-diabetic activity, Alloxan, Glibenclamide, Liposomes

Abstract

The antidiabetic activity of Glibenclamide loaded liposomes was investigated in model of alloxan-induced diabetes inrats. The blood glucose level was measured at 0 h and 1, 2, 4, 6, 8, 10, 12, 14 and 16h after the treatment. The alloxan– diabetic rats showed signifi cant reduction in blood glucose level, after treatment with Glibenclamide loaded liposomesand orally Glibenclamide (used as standard) as compared to diabetic control. The antidiabetic effect of liposomes wascompared with the reference standard drug Glibenclamide (5mg/kg). In conclusion, our result showed that the liposomesloaded glibenclamide when administered by i.p. may reduce blood glucose level. These results suggested the validity ofclinical use of Glibenclamide loaded liposomes.

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References

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Published

2007-04-20

How to Cite

1.
SINGH M, BALAMURUGAN M, GUPTA A, YADAV S, SHARMA A, ACHARYA A, RAMASAMY M. Antidiabetic Activity of Glibenclamide Loaded Liposomes in Alloxan Induced Diabetic Rats. Ars Pharm [Internet]. 2007 Apr. 20 [cited 2024 Jul. 22];48(1):31-6. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4976

Issue

Vol. 48 No. 1 (2007)

Section

Original Articles

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