Comparative Investigation on in vitro release of extemporaneously prepared norfloxacin semisolid formulations with marketed silver sulfadiazine 1% cream, USP using model independent approach

Authors

  • K Dua Lecturer, Dept. of Pharmaceutical Technology, School of Pharmacy & Allied Health Sciences, International Medical University, Bukit Jalil, Malaysia
  • K Pabreja Lecturer, Dept. of Life Sciences, School of Pharmacy & Allied Health Sciences, International Medical University, Bukit Jalil, Malaysia.
  • MV Ramana Professor, VIT University, Vellore, Tamilnadu, India

Keywords:

Semisolid, Ointments, Norfloxacin

Abstract

Objective

In an attempt for better treatment of bacterial infections, various semisolid formulations containing 5%w/w of norfloxacin were prepared and evaluated for in vitro drug release and in vitro skin permeabilityusing dialysis membrane and rat abdominal skin respectively. The in vitro diffusion and permeationprofile of the prepared formulation was compared with marketed silver sulfadiazine cream 1%, USPusing model independent approach.

Methods

Various semisolid formulations were prepared with different dermatological bases usingstandard procedures. In vitro diffusion and permeation studies were carried out using Keshary-Chein(KC) type diffusion cell using dialysis membrane and rat abdominal skin respectively.

Results

The f1 lower than 15 and f2 higher than 50 indicated similarities in the in vitro diffusion andpermeation profiles of the extemporaneously prepared selected semisolid formulations and marketedsilver sulfadiazine 1% cream, USP.

Conclusion

Amongst all the semisolid formulations prepared, carbopol gel base was found to be most suitabledermatological base for norfloxacin, the results obtained for in vitro diffusion, and in vitro skinpermeation studies are comparable with that of marketed silver sulphadiazine 1% cream, USP.

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Published

2010-12-20

How to Cite

1.
Dua K, Pabreja K, Ramana M. Comparative Investigation on in vitro release of extemporaneously prepared norfloxacin semisolid formulations with marketed silver sulfadiazine 1% cream, USP using model independent approach. Ars Pharm [Internet]. 2010 Dec. 20 [cited 2024 May 18];51(4):177-85. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4876

Issue

Vol. 51 No. 4 (2010)

Section

Original Articles

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