Formulation and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Domperidone hydrochloride

Authors

  • S Latha Department of Pharmaceutical Technology, Anna University Tiruchirappalli, Tiruchirappalli – 620 024, Tamil Nadu, India.
  • P Selvamani Department of Pharmaceutical Technology, Anna University Tiruchirappalli, Tiruchirappalli – 620 024, Tamil Nadu, India.
  • S Lakshmana Prabu Department of Pharmaceutical Technology, Anna University Tiruchirappalli, Tiruchirappalli – 620 024, Tamil Nadu, India.
  • P Santhosh Kumar Department of Pharmaceutical Technology, Anna University Tiruchirappalli, Tiruchirappalli – 620 024, Tamil Nadu, India.
  • TK Pal Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700 032

Keywords:

Domperidone hydrochloride, Eudragit RL, Eudragit RS, Release studies, Transdermal patch

Abstract

A matrix dispersion type transdermal drug delivery system of domperidone was developed using different ratios of rosin with Eudragit RL and Eudragit RS. The effect of the polymers on the technological properties, i.e., drug release, water vapor transmission rate, percentage moisture loss and thickness were investigated. The patch containing Eudragit RL: Eudragit RS (8:2) showed a release of 87.10% in 12 h. Formulation D1 emerged as the most satisfactory formulation as far as the technological properties were concerned. Further skin permeation and skin irritation studies were carried out on rat skin and rabbit respectively. Therefore it can be concluded that the patch containing Eudragit RL: Eudragit RS in the ratio 8:2 achieved the desired objectives of transdermal drug delivery systems, such as overcoming of first pass effect, extended release and reduced frequency of administration

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References

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Published

2011-03-20

How to Cite

1.
Latha S, Selvamani P, Lakshmana Prabu S, Santhosh Kumar P, Pal T. Formulation and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Domperidone hydrochloride. Ars Pharm [Internet]. 2011 Mar. 20 [cited 2024 Jul. 22];52(1):31-6. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4712

Issue

Vol. 52 No. 1 (2011)

Section

Original Articles

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