Fabrication and characterization of solid lipid microparticles of ketoprofen

Authors

  • S Mishra Faculty of Pharmacy, Babu Banarsi Das National Institute of Technology and Management, Lucknow, U.P, India-227105.
  • R Suryawanshi Faculty of Pharmacy, Babu Banarsi Das National Institute of Technology and Management, Lucknow, U.P, India-227105.
  • V Chawla Faculty of Pharmacy, Northern India Engineering College, Lucknow, U.P. India
  • S Saraf Faculty of Pharmacy, Babu Banarsi Das National Institute of Technology and Management, Lucknow, U.P, India-227105.

Keywords:

Solid lipid microparticles, ketoprofen, solvent evaporation method

Abstract

Solid lipid microparticles (SLMs) loaded with ketoprofen were prepared by single emulsion-solvent evaporation method, in which glyceryl monostearate and Tween 80 were employed. The particle size was found to be 99.80±2.1μm. Microparticles observed by scanning electron microscope (SEM) showed spherical shape. The entrapment efficiency (EE %) and drug loading capacity (DL %) were found to be 72.60±1.6 % and 17.98±0.7% respectively. Results of stability evaluation showed relatively long term stability after storage at 4˚C for 3 months. The in-vivo study revealed slightly better per cent inhibition of pain i.e. 74% in comparison with 68% produced by plain drug.

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References

Jaspart S, Piel G, Delattre, L. Solid lipid microparticles: formulation, preparation characterization, drug release and applications- a review. Expert Opin Drug Deliv. 2005; 2: 1-12.

Muller RH, Mader K, Gohla S. Solid lipid nanoparticles for controlled drug delivery - a review of the state of art. Eur. J Pharm Biopharm. 2000; 50: 161-177.

Takayama K, Nagai, T. Simultaneous optimization for several characteristics concerning percutaneous absorption and skin damage of ketroprofen hydrogels containing d-limonene. Int J Pharm. 1991; 74: 115-126.

De Bernardi DVM, Tripodi, AS, Contos S. Steady state pharmacokinetics of a sustained released formulation of ketoprofen in comparison with normal release formulation. Acta Toxicol Ther. 1994; 15: 93-112.

Ahm HJ, Kim KM, Kim CK. Enhancement of bioavailability of ketoprofen using dry elixir as a novel dosage form. Drug Dev Ind Pharm 1998; 24: 697-701.

Peh KK, Wong CF, Yuen KH. Possible mechanism for drug retardation from glyceryl monostearate matrix system. Drug Dev Ind Pharm. 2000; 26: 447-450.

Peh KK, Yuen KH. In-vivo performance of a multiparticulate matrix controlled release theophylline. Drug Dev Ind Pharm. 1995; 22: 349-355.

Kwon S, Joo J, Lee W, Jeong Y, Choi J. Polymeric Nano-half-shells prepared by simple solvent evaporation method. Bull. Korean Chem. Soc. 2009; 30:486-488.

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Published

2011-03-20

How to Cite

1.
Mishra S, Suryawanshi R, Chawla V, Saraf S. Fabrication and characterization of solid lipid microparticles of ketoprofen. Ars Pharm [Internet]. 2011 Mar. 20 [cited 2024 Jul. 22];52(1):12-5. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4697

Issue

Vol. 52 No. 1 (2011)

Section

Original Articles

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