Immunomodulatory activity of Bauhinia Racemosa Lam.

Authors

  • Sohrab A Shaikh Department of Pharmacology, Pad.Dr.D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India
  • Mahesh M. Ghaisas Department of Pharmacology, Pad.Dr.D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India
  • Avinash D. Deshpande Department of Pharmacology, Pad.Dr.D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India

Keywords:

Bauhinia Racemosa, immunomdulatory, neutrophil adhesion, phagocytosis

Abstract

Aim: To evaluate immunomodulatory activity of methanolic extract of stem bark of Bauhinia racemosa Lam swiss albino mice.

Material and Methods: The specific humoral immunity was assessed by performing hemagglutinating antibody titer (H.A.Titer) and the non-specific immunity was assessed by performing carbon clearance test and neutrophil adhesion test.

Results: The methanolic extract of stem bark of Bauhinia Racemosa (MEBR) was found effective in increasing the H.A.Titer. Primary and secondary antibody response showed no significant rise in H.A.Titer in normal immune status group when compared with control group, whereas in immunosupressed group, where immunity was suppressed by cyclophosphamide, significant rise in H.A.Titer (p<0.01) was observed at dose of 200 mg/kg (p.o.) when compared with cyclophosphamide. MEBR showed significant increase (p<0.05) in phagocytic activity at dose of 200 mg/kg (p.o.) in carbon clearance test. In neutrophil adhesion test MEBR showed significant (p<0.01) rise in percentage neutrophil adhesion at dose of 200 mg/kg (p.o.).

Conclusion: Present study, therefore, reveals that MEBR) holds promise as immunomodulatory agent.

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Published

2012-09-20

How to Cite

1.
Shaikh SA, Ghaisas MM, Deshpande AD. Immunomodulatory activity of Bauhinia Racemosa Lam. Ars Pharm [Internet]. 2012 Sep. 20 [cited 2024 Jul. 22];53(3):01-6. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4678

Issue

Vol. 53 No. 3 (2012)

Section

Original Articles

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