Microorganismos probióticos y salud.

Authors

  • María Teresa Sánchez Departamento de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia. Universidad de Granada (España).
  • María Adolfina Ruiz Departamento de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia. Universidad de Granada (España).
  • María Encarnación Morales Departamento de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia. Universidad de Granada (España).

DOI:

https://doi.org/10.4321/s2340-98942015000100007

Keywords:

Health, Pharmaceutical Preparations, Probiotic

Abstract

Aims: Show the benefits of the probiotic microorganisms on health and its acceptance by the consumer. As well as collect those probiotic products available in pharmaceutical market.

Materials and methods: A study of the pharmaceutical marketin relation to the existing dosage forms with probiotic microorganisms and their evolution in recent years was made. Classifying probiotic products was conducted according to the dosage form in which they are presented; each product must be accompanied by the dose of probiotic-containing, expressed as Colony Forming Units(CFU).

Results: It is increasing the number of probiotic strains isolated and the benefits that its shown on human health. We found a diversity of probiotic products available in pharmacies as a result of an increasing demand by consumers; it is important to note that many of them lack necessary information on packaging, for example, the dose contained.

Conclusions: The interest of the pharmaceutical industry in develop new dosage forms contained in probiotic microorganisms will be growing and will be linked to the need for a specific regulation for these products. Many of them do not contain the required dose to obtain a beneficial effect on health which is misleading advertising to consumers, therefore, they should be removed from the market, advertising only those products which contain a therapeutic dose and whose effects are endorsed by various clinical trials.

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References

Champagne CP, Ross RP, Saarela M, Hansen KF, Charalampopoulos D. Recommendations for the viability assessment of probiotics as concentrated cultures and in food matrices. Int J Food Microbiol. 2011; 149: 185-193.

Dubey AP, Rajeshwari K, Chakravarty A, Famularo G. Use of VSL#3 in the treatment of rotavirus diarrhea in children: preliminary results. J Clin Gastroenterol.2008; 42 (Suppl. 3 Pt 1): 126-129.

Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R. Probiotics for the prevention and treatment of antibiotic-associated diarrhea:a systematic review and meta-analysis. JAMA.2012; 307:1959–69.

De Vrese M, Offick B. Probiotics and Prebiotics: Effects on Diarrhea. Bioactive Foods in Promoting Health: Probiotics and Prebiotics. 2010; Chapter 14.

Meijer BJ, Dieleman LA. Probiotics in the treatment of human inflammatory bowel diseases. J ClinGastroenterol. 2011; 45: 139–144.

Guslandi M et al. Saccharomyces boulardii in maintenance treatment of Crohn’s disease. Dig Dis Sci. 2000; 45: 1462–1464.

Montalto M, Curigliano V, Santoro L et al. Management and treatment of lactose malabsorption. World J Gastroenterol. 2006; 12:187–191.

Gotteland M, Brunser O, Cruchet S. Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori? Aliment PharmacolTher. 2006; 23: 1077-1086.

Alexandre Y, Le Blay G, Boisramé-Gastrin S, Le Gall F, Héry-Arnaud G, Gouriou S, Vallet S, Le Berre R. Probiotics: A new way to fight bacterial pulmonary infections? Les probiotiques: une nouvelle armethérapeutiquecontre les infections respiratoires?. Med Mal Infect. 2014; 44: 9- 17.

Larsen LA, Raben A, Haulrik N, Hansen AS, Manders M, Astrop A. Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J ClinNutr. 2000; 54: 288-297.

Xiao JZ, Kondo S, Takahashi N et al. Effects of milk products fermented by Bifidobacteriumlongum on blood lipids in ratsand healthy adult male volunteers. J Dairy Sci. 2003; 86 (7): 2452-2461.

Tulika A, Satvinder S, Kumar Sharma R. Probiotics: Interaction with gut microbiome and antiobesity potential. Nutrition. 2013; 29: 591–596.

Qin J, Li Y, Cai Z, Li S et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012; 490:55–60.

Waligora-Dupriet AJ, Butel MJ. Microbiota and allergy: from dysbiosis to probiotics. En: Pereira C, editor. Allergic diseases–highlights in the clinic, mechanisms and treatment. 2012;p 413–434.

Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. ClinExpImmunol. 2010; 160:295–304.

Bunselmeyer B, Buddendick K. Probiotics and Prebiotics—Prevention and Therapy in Atopic Eczema. Bioactive Foods in Promoting Health: Probiotics and Prebiotics. 2010

Serban DE. Gastrointestinal cancers: Influence of gut microbiota, probiotics and prebiotics. Cancer letter. 2013; 345: 258-270.

Iannitti T, Palmieri B. Therapeutical use of probiotic formulations in clinical practice. Clinical Nutrition. 2010; 29:701-725.

Theodorakopoulou M, Perros E, Giamarellos-Bourboulis EJ, Dimopoulos G. Controversies in the management of the critically ill: the role of probiotics. Int J Antimicrob Agents. 2013; 42S: S41-S44.

Gupta V, Garg R. Probiotics. Indian J Med Microbiol. 2009; 136: 2015-2031.

Huang Y, Adams MC. In vitro assessment of the upper gastrointestinal tolerance of potential probiotic dairy propionibacteria. Int J Food Microbiol. 2004; 91(3): 253-260.

Chaikham P, Apichartsrangkoon A, Jirarattanarangsri W, Van de Wiele T. Influence of encapsulated probiotics combined with pressurized longan juice on colon microflora and their metabolic activities on the exposure to simulated dynamic gastrointestinal tract. Food Res Int. 2012; 49: 133-142.

Foligné B, Daniel C, Pot B. Probiotics from research to market: the possibilities risk and challenges. CurrOpinMicrobiol. 2013; 16: 284-292.

CIM (Centro InformaciónMedicamento).

https://www.casenfleet.com [consulta 10/03/2014]

https://www.salvatbiotech.com [consulta 10/03/2014]

https://www.suplements.com[consulta 10/03/2014]

https://www.stada.es [consulta 10/03/2014]

https://www.sorianatural.es[consulta 10/03/2014]

https://www.arkopharma.es[consulta 11/03/2014]

https://www.pileje.es[consulta 11/03/2014]

https://www.aquilea.com [consulta 11/03/2014]

https://www.nutergia.es[consulta 12/03/2014]

https://www.inneov.es [consulta 12/03/2014]

https://www.dhu.es [consulta 13/03/2014]

https://www.bayer.es[consulta 13/03/2014]

https://www.ordesa.es [consulta 14/03/2014]

Brandy LJ, Gallaher DD, Busta FF. The role of probiotic cultures in the prevention of colon cancer. J Nutr. 2000; 130 (suppl. 2S): 410S-414S.

Chen CC, Louie S, Shi HN, Walker WA. Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacterrodentium colitis. Pediatr Res. 2005; 58: 1185–1191.

De Vrese M, Offick B. Bioactive Foods in Promoting Health. Institute of Physiology and Biochemistry of Nutrition, Federal Dairy Research Center, Kiel, Germany. 2005; 205- 227.

Elmer GW, McFarland LV. Biotherapeutic agents in the treatment of infectious diarrhea. GastroenterolClin. 2001; 30: 837-854.

Furrie E. Probiotics and allergy. ProcNutr Soc. 2005; 64:465–469.

Galvez J, Comalada M, Xaus J. Prebiotics and Probiotics in Experimental Models of Rodent Colitis: Lessons in Treatment or Prevention of Inflammatory Bowel Diseases. Bioactive Foods in Promoting Health: Probiotics and Prebiotics. 2010; Chapter 35.

Ghadimi D, Fölster- Holst R, de Vrese M, Winkler P, Heller KJ, Scherenmeir J. Effect of probiotic bacteria and their genomic DNA on Th1/ th2- cytokine production by peripheral blood mononuclear cells of healthy and allergic subjects. Inmunobiology. 2008; 213: 677-692.

Guarino A, Canani NB, SpagnuoloMI. Oral bacterial therapy reduces the duration of symptons and of viral excretion in children with mild diarrea. J PediatrGastroenterolNutr.1997; 25:516-519.

Homayoni A, Vaghef E, Alipoor B, Vaghef L, JavadiM. Do probiotics act more efficiently in foods than in supplements? Nutrition. 2012; 28: 733-736.

Kalliomaki MA, Isoulari E. Probiotics and down regulation of the allergic response.Inmunol Allergy Clin North Am. 2004 ;24: 739-752.

Kieran M, Hollie M, Chris W, Glann R. Using probiotics and prebiotics toimprove gut health. DDT. 2003; 8: 692- 700.

Lara-Villoslada F, Olivares M, Xaus J. Safety of probiotic bacteria. Bioactive Foods in Promoting Health: Probiotics and Prebiotics. 2010; 4: 47-58.

Lievin L, Peiffer V, Hudault I et al. Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut. 2000; 47: 646–652.

Lin MY, Yen CL, Chen SH. Management of lactose maldigestion by consuming milk containing Lactobacilli. Dig Dis. 1998; 43: 133-137.

López C, De la Cruz J, Urbanos C. Uso potencial de los probióticos.FMC. 2006; 13(10): 622-627.

Madsen K, Cornish A, Soper P et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology. 2001; 121: 580–591.

Marteau P, Shanahan F. Basic aspects and pharmacology of probiotics: an overview of pharmacokinetics, mechanisms of action and side-effects. BestPract Res ClinGastroenterol. 2003; 17: 725-740.

McFarland LV. Epidemiology, risk factors and treatments for antibiotic associated diarrhea. Dig Dis. 1998; 16: 292-307.

Morrison D J, Mackay WG, Edwards CA et al. Butyrate production from oligofructose fermentation by the human faecal flora: What is the contribution of extracellular acetate and lactate? Br J Nutr. 2006; 96: 570–577.

Nguyen TD, Kang JH, Lee MS. Chacarterization of Lactobacillus plantarumPH04, a potential probiotic bacterium with cholesterol-lowering effects. Int J Food Microbiol. 2007; 113: 358-361.

Ouwehand AC, Salminen S, Isolauri E. Probiotics: an overview of beneficial effects. Antonie Van Leeuwenhoek. 2002; 82: 279-289.

Patel A, Shah N, Prajapati JB. Clinical appliance of probiotics in the treatment of Helicobacter pylori infection- a brief review. MikrobiolZh. 2013; XX: 1-9.

Podolsky DK. Inflammatory Bowel Disease. N Engl J Med.2002; 347 (6): 417-421.

Preidis GA, Versalovic J. Targeting the human Microbiome with antibiotics, probiotics and prebiotics: gastroenterology enters the metagenomics era. Gastroenterology. 2009; 136:2015-2031.

RamosA, Monteoliva M, Nader FE, editores. Probióticos y salud. Parte segunda: Probióticos y Salud Humana. Capítulos 3, 4,7, 8,9, 15, 21, 24, 25,26.

Sanders ME, Heimbach JT, Pot B et al. Health claims substantiation for probiotic and prebiotic products. Gut microbes. 2011; 2: 127-133.

Schultz M, Linde HJ, Lehn N et al. Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain GG in healthy volunteers. J Dairy Res. 2003; 70: 165–173.

Talaie F, Atyabi F, Azjdarzadeh M, Dinarvand R, SaadatzadehA. Overcoming therapeutic obstacles in inflammatory bowel diseases: A comprehensive review on novel drug delivery strategies. Eur J Pharm Sci. 2013; 49: 712-722.

Taranto MP, Medici M, Perdigon G, Ruiz Holgado AP, Valdez GF. Evidence for hypocholesterolemic effect of Lactobacillus reuteri in hypercholesterolemic mice. J Dairy SCi. 2000; 81: 2336- 2340.

Zhu Y, Luo M, Jobin C, Young H. Gut microbiota and probiotics in colon tumorigenesis. Cancer Letters. 2011; 309: 119-127.

Zyrek A A, Cichon C, Helms S et al. Molecular mechanisms underlying the probiotic effects of Escherichia coliNissle 1917 involve ZO–2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol.2007; 9: 804–816.

Published

2015-03-20

How to Cite

1.
Sánchez MT, Ruiz MA, Morales ME. Microorganismos probióticos y salud. Ars Pharm [Internet]. 2015 Mar. 20 [cited 2024 Jul. 22];56(1):45-59. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4264

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Section

Special Articles