Prescribing pattern of antihypertensive drugs in diabetic patients of Southern Province, Kingdom of Saudi Arabia
DOI:
https://doi.org/10.4321/s2340-98942015000200005Keywords:
Hypertension, Diabetes, Antihypertensive agentsAbstract
Background. Hypertension is extremely prevalent in patients with diabetes. Limited data exist on utilizationpatterns of antihypertensive in this population are consistent with evidence-based practice guidelines.
Objective. To evaluate utilization patterns of antihypertensive agents among diabetic patients with hypertension.
Design. Retrospective descriptive cross sectional.
Patients / Participants. 149 patients with diabetes and hypertension from outpatient department at FamilyMedicine Hospital, Ahaderfieda. Khamis Mushait, K.S.A.
Results. Over 43% of patients were receiving calcium channel blockers (CCB), 36.2 % of received angiotensinconverting enzyme inhibitors (ACEI), followed by angiotensin receptor blockers (ARBs) (34.9%),diuretics (34.2%) and β -blockers (16.2%). Patients on monotherapy were mostly receiving CCB (34.3%)and ACEI (29.9%). The majority (55.03%) of treated patients were on multidrug regimens. In patientswith coronary artery disease (CAD), a diuretic with ACEI (25%) and calcium channel blocker with angiotensinreceptor blocker (25%) was most commonly prescribed.
Conclusions. Patterns of antihypertensive therapy were generally consistent with international guidelines.Areas of improvement include increasing ACEI/ARB and diuretic use, decreasing the number ofuntreated patients, and increasing the proportion of patients with controlled BP in this population.
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References
El-Hazmi MA, Warsy AS. Association of hypertension and
non-insulin-dependent diabetes mellitusin the Saudi population.
Ann Saudi Med. 2001; 21(1-2):5-8.
Al-Baghli NA, Al-Ghamdi AJ, Al-Turki KA, Al Elq AH, El-
Zubaier AG, Bahnassy A. Prevalence of diabetes mellitus
and impaired fasting glucose levels in the Eastern Province
of Saudi Arabia: results of a screening campaign. Singapore
Med J. 2010; 51(12):923-30.
Preliminary Report on the Results of Monitoring of Risk Factors
for Non-Communicable Diseases in the Kingdom of Saudi
Arabia. Riyadh: King Fahad National Library; 2005.
Dhanaraj E, Raval A, Yadav R, Bhansali A, Tiwari P. Prescription
Pattern of Antihypertensive Agents in T2DM Patients
Visiting Tertiary Care Centre in North India. Int J Hypertens.
; 2012:520915. doi: 10.1155/2012/520915.
Chobanian AV et al.. The Seventh Report of the Joint National
Committee on Prevention, Detection, Evaluation, and Treatment
of High Blood Pressure: the JNC 7 report. JAMA. 2003;
(19):2560-72.
Shah J, Khakhkhar T, Bhirud S, Shah RB, Date S. Study of utilization pattern of anti-hypertensive drugs in hypertensive
diabetic patients with or without reduced renal function at tertiary care teaching hospital. Int J Med Sci Public Health. 2013; 2(2): 175-180.
Berlowitz DR1, Ash AS, Hickey EC, Glickman M, Friedman R, Kader B. Hypertension management in patients with diabetes: the need for more aggressive therapy. Diabetes Care. 2003; 26(2):355-9.
Saudi Hypertension Management Guidelines, Saudi Hypertension
Management Society, 2011.
Arauz-Pacheco C1, Parrott MA, Raskin P.The treatment of
hypertension in adult patients with diabetes. Diabetes Care. 2002; 25(1):134-47.
Sowers JR, Haffner S. Treatment of cardiovascular and renal risk factors in the diabetic hypertensive. Hypertension 2002; 40:781-8.
Sowers JR, Reed J. 1999 Clinical Advisory Treatment of Hypertension and Diabetes. J Clin Hypertens (Greenwich) 2000;
:132-3.
Sharminder Kaur S , Gupta S , Kumar D , Lal M , Gilani Z. Prescribing pattern of antihypertensive drugs in a tertiary care hospital in Jammu- A Descriptive study. JK-Practitioner 2012; 17 (4): 38-41.
The Seventh Report of the Joint National Committee on Prevention,
Detection, Evaluation, and Treatment of High Blood Pressure. National High Blood Pressure Education Program. Source Bethesda (MD): National Heart, Lung, and Blood Institute (US); 2004. Report No.: 04-5230.
Fox KM ; EURopean trial On reduction of cardiac events with
Perindopril in stable coronary Artery disease Investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).Lancet. 2003; 362 (9386):782-8.
McAlister FA, Campbell NR, Duong-Hua M, Chen Z, Tu K.
Antihypertensive medication prescribing in 27,822 elderly Canadians with diabetes over the past decade. Diabetes Care.
; 29(4):836-41.
Richards M. The Safety of Calcium Antagonists: An Update. Prescriber Update. 2000; 19: 4–13.
Wald DS, Law M, Morris JK, et al.. Combination therapy versus
monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009; 122:290-300.
Vogel Anderson KL, Combination Therapy in Hypertension Management. US Pharm. 2012; 37(6):46-50.
Kale A, Maniyar YA. Prescribing patterns of antihypertensive drugs in a tertiary care hospital. Sch Acad J Pharm. 2013; 2(5):416-418.
Gu Q, Burt VL, Dillon CF, Yoon S. Trends in antihypertensive
medication use and blood pressure control among United States adults with hypertension: the National Health and Nutrition Examination Survey, 2001 to 2010. Circulation. 2012; 126(17):2105-14.
Skolnik NS, Beck JD, Clark M. Combination antihypertensive drugs: recommendations for use. Am Fam Physician. 2000; 61(10):3049-56.
Escobar C, Barrios V. Calcium channel blocker-based combination
therapy. The best approach in the treatment of highrisk hypertension? Int J Clin Pract. 2008; 62(5):670-2.
Kalra S, Kalra B, Agrawal N. Combination therapy in hypertension:
An update. Diabetol Metab Syndr. 2010; 2(1):44. doi: 10.1186/1758-5996-2-44.
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