Relationship between radiochemical purity of 123i-ioflupane and extracranial image captation (parotid and thyroid)

Authors

  • Lucía Díaz Platas Unidad de Radiofarmacia Hospital Clínico Universitario de Valencia
  • Stefan Prado Wohlwend Servicio de Medicina Nuclear Hospital Clínico Universitario de Valencia
  • Monica Romero Otero Unidad de Radiofarmacia Hospital Clínico Universitario de Valencia
  • Alba Iniesta Medel Servicio de Medicina Nuclear Hospital Universitario Politécnico La Fe
  • Luis Ramudo Cela Servicio de Farmacia Complexo Hospitalario Universitario da Coruña

Keywords:

Ioflupane, 123Iodure, Radiocromatography, Radiochemical, Thyroid captation, Thin layer chromatography

Abstract

Aim. The aim of this study is to see the effect of radiochemical purity (PR) of 123I- Ioflupane used for cerebral dopamine transporter SPECT (Single Photon Emission Computed Tomography) on the images and evaluate the possible influence of extravasation during the administration in patient with Parkinson syndrome.

Material and methods. A Prospective study was performed in 39 patients. The PR of 123I-Ioflupane was determined by radiochromatography.

The regions of interest (ROI) were defined in general area of the brain, parotid and cervical region, obtaining the average counts in each region and activity ratios thyroid / brain (RTC) and parotid / brain (RPC). It was proposed a model of multiple linear regression with quantitative and categorical predictors

Results. The model showed that correlation between the PR and the RTC was modified by the presence of extravasation, it was statistically significant (p < 0.001) and predicted the 42.31 % of the variability of the RTC. The correlation between PR and PRC was not modified by any of the variables proposed. The model was statistically significant (p < 0.0176) and 12.3% predicted variability RPC.

Conclusions. The predictive variability of the model of RTC is acceptable and explains the negative impact of extravasation. However, the ability to explain the variability of the PRC is low and should not be attributed to variables studied. A low PR and extravasation during the administration of the radiopharmaceutical involves worse quality of image and increased thyroid irradiation.

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References

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Published

2015-12-20

How to Cite

1.
Díaz Platas L, Prado Wohlwend S, Romero Otero M, Iniesta Medel A, Ramudo Cela L. Relationship between radiochemical purity of 123i-ioflupane and extracranial image captation (parotid and thyroid). Ars Pharm [Internet]. 2015 Dec. 20 [cited 2024 Jul. 22];56(4):225-30. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/3872

Issue

Vol. 56 No. 4 (2015)

Section

Original Articles

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