Comparación de la estimulación por microvibración versus inhibidores de catepsina K a nivel molecular y celular: una revisión sistemática

Yomira Salgado Martínez; Rosina Eugenia Villanueva Arriaga; Salvador García López; Nelly Molina Frechero

doi:10.30827/ars.v65i4.30321

Authors

Yomira Salgado Martínez Maestría en ciencias odontológicas, Ciudad de México. https://orcid.org/0000-0002-7161-4822
Rosina Eugenia Villanueva Arriaga Universidad Autónoma Metropolitana, Maestría en Ciencias Odontológicas, CDMX, Ciudad de México
Salvador García López Universidad Autónoma Metropolitana, Maestría en Ciencias Odontológicas, CDMX, Ciudad de México.
Nelly Molina Frechero Universidad Autónoma Metropolitana, Maestría en Ciencias Odontológicas, CDMX, Ciudad de México.

DOI:

https://doi.org/10.30827/ars.v65i4.30321

Keywords:

bone, osteoclast, osteoporosis, enzyme, cathepsin, treatment

Abstract

Introduction: Bone is constantly remodeling to maintain the structure of the bone tissue that composes it. This is susceptible to changes that can be both favorable and harmful, marked by certain variables such as age, sex, diseases, hormonal alterations, trauma, among others.

Method: Due to the above, the idea was raised to study which treatment is better in the regeneration of bone tissue, comparing pharmacological treatments (cathepsin K inhibitors) against micro-vibratory stimulation or non-pharmacological treatment.

Objective: To carry out a systematic review of treatments with microvibrations and cathepsin K inhibitors in relation to bone remodeling.To make a comparison between the effectiveness of treatment based on micro-vibrations and with cathepsin K inhibitors, a systematic review was carried out in nine databases (Wiley Online Library, Pubmed, Google Academic, Scopus, Science Direct, Scielo , Medline, EBSCO and SpringerLink).

Results: Twenty articles were included in this study, which demonstrated that both treatments improve the bone remodeling process.

Conclusions: Taking into consideration the systematic review carried out, it has been determined that the treatment of low-intensity, high-frequency micro-vibrations increases the outer cortex; however, the use of cathepsin k inhibitors promises innovative treatments in tissue regeneration.

Downloads

Download data is not yet available.

References

Aristizábal J. Ortodoncia acelerada y ortodoncia de transito expreso (OTE)®, un concepto contemporáneo de alta eficiencia. CES odontol. 2014; 27(1): 56-73.

Kafienah W, Bromine D. Human Cathepsin k cleaves native type I and II collagens at the N-terminal end of the Triple Helix. Biochem J. 1998; 33(3): 727-732 doi: 10.1042/bj3310727. DOI: https://doi.org/10.1042/bj3310727

Page M, McKenzie J. La declaración PRISMA 2020: una guía actualizada para informar revisiones sistemáticas. BMJ. 2021; 372: n71. doi: 10.1136 / bmj.n71.

da-Costa-Santos C. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. 2007; 15(3): 508-511 Doi: 10.1590/s0104-11692007000300023. DOI: https://doi.org/10.1590/S0104-11692007000300023

Jadad AR. “Assessing the quality of reports of randomized clinical trials: Is blinding necessary?” Controlled Clinical Trials. 1996; 17(1): 1-12 doi:10.1016/0197-2456(95)00134-4. DOI: https://doi.org/10.1016/0197-2456(95)00134-4

Higgins J. Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane. 2021; www.training.cochrane.org/handbook.

McGuinness L, Higgins J. Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Res Syn Meth. 2020; 1- 7. doi: 10.1002/jrsm.1411. DOI: https://doi.org/10.1002/jrsm.1411

García-López S, Villanueva R, Massó-Rojas F. Micro-vibrations at 30 Hz on bone cells cultivated in vitro produce soluble factors for osteoclast inhibition and osteoblast activity. Arch Oral Biol. 2020; 110(104594): 1-9 doi: 10.1016/j.archoralbio.2019.104594. DOI: https://doi.org/10.1016/j.archoralbio.2019.104594

Higashi Y. Effect of low intensity pulsed ultrasound on osteoclast differentiation. Orthod Waves. 2020; 74(4): 163-169 doi: 10.1080/13440241.2020.1843354. DOI: https://doi.org/10.1080/13440241.2020.1843354

Cai J, Shao X. Differential skeletal response in adult and aged rats to independent and combinatorial stimulation with pulsed electromagnetic fields and mechanical vibration. FASEB J. 2020; 34(2): 3037-3050 doi: 10.1096/fj.201902779R. DOI: https://doi.org/10.1096/fj.201902779R

Alikhani M. Therapeutic effect of localized vibration on alveolar bone of osteoporotic rats. PLoS ONE. 2019; 14(1): e0211004 doi: 10.1371/journal.pone.0211004. DOI: https://doi.org/10.1371/journal.pone.0211004

Li X, Liu D, Li J. Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model. FASEB J. 2019; 33(8): 8913-8924 doi: 10.1096/fj.201802711R. DOI: https://doi.org/10.1096/fj.201802711R

Wu S, Zhong Z, Chen J. Low-magnitude high-frequency vibration inhibits RANKL-induced osteoclast differentiation of RAW264.7 cells. Int J Med Sci. 2012; 9(9): 801-807 doi: 10.7150/ijms.4838. DOI: https://doi.org/10.7150/ijms.4838

Zhou J, Li X, Liao Y, Feng W. Effects of electroacupuncture on bone mass and cathepsin K expression in ovariectomised rats. Acupunct Med. 2014; 32(6): 478-485 doi: 10.1136/acupmed-2014-010577. DOI: https://doi.org/10.1136/acupmed-2014-010577

Yamaguchi M, Hayashi M. Low-energy laser irradiation facilitates the velocity of tooth movement and the expressions of matrix metalloproteinase-9, cathepsin K, and alpha(v) beta(3) integrin in rats. Eur J Orthod. 2010; 32(2): 131-139 Doi: 10.1093/ejo/cjp078 . DOI: https://doi.org/10.1093/ejo/cjp078

Panwar P, Xue L. An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice. J. Bone Miner. Res. 2017; 34(4): 777-778 doi:10.1002/jbmr.3227. DOI: https://doi.org/10.1002/jbmr.3687

Liu H, Zhu R. Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats. Int. j. phytother. Res. 2018; 32: 2487– 2500 doi: 10.1002/ptr.6188. DOI: https://doi.org/10.1002/ptr.6188

Yamashita T, Hagino H, Hayashi I. Effect of a cathepsin K inhibitor on arthritis and bone mineral density in ovariectomized rats with collagen-induced arthritis. Bone. 2018; 9: 1-10 doi:10.1016/j.bonr.2018.05.006. DOI: https://doi.org/10.1016/j.bonr.2018.05.006

Shi X, Li C. Drynaria total flavonoids decrease cathepsin K expression in ovariectomized rats. Genet Mol Res. 2014; 13(2): 4311-4319 doi: 10.4238/2014.June.9.17. DOI: https://doi.org/10.4238/2014.June.9.17

Ochi Y, Yamada H, Mori H. ONO-5334, a cathepsin K inhibitor, improves bone strength by preferentially increasing cortical bone mass in ovariectomized rats. 0542-x . J. Bone Miner. Metab. 2013; 13(6): 645–652 doi:10.1007/s00774-013-0542-x. DOI: https://doi.org/10.1007/s00774-013-0542-x

Yu N, Fathi A, Murphy C. Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheres. J Biomed Mater Res Part B. 2015 2015:00B:000–000.; 00(B): 0-8 Doi:10.1002/jbm.b.33481. DOI: https://doi.org/10.1002/jbm.b.33481

Suzuki N, Takimoto K, Kawashima N. Cathepsin K Inhibitor Regulates Inflammation and Bone Destruction in Experimentally Induced Rat Periapical Lesions. J Endod7. 2015; 41(9): 1474–1479 doi: 10.1016/j.joen.2015.04.013. DOI: https://doi.org/10.1016/j.joen.2015.04.013

Yoshioka Y, Yamachika E, Nakanishi M. Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats. Br J Oral Maxillofac Surg. 2017; 56(8): 732-738 doi.org/10.1016/j.bjoms.2018.08.003. DOI: https://doi.org/10.1016/j.bjoms.2018.08.003

Araújo AA. Azilsartan Increases Levels of IL-10, Down-Regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and Up-Regulates OPG in an Experimental Periodontitis Model. PLoS ONE. 2014; 9(5): e96750 doi:10.1371/journal.pone.0096750. DOI: https://doi.org/10.1371/journal.pone.0096750

Hao L, Zhu G, Lu Y. Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role. FEBS Letters. 2015; 589(12): 1331–1339. doi:10.1016/j.febslet.2015.04.008. DOI: https://doi.org/10.1016/j.febslet.2015.04.008

Zhang W, Dong Z, Li D, Li B, Liu Y. Cathepsin K deficiency promotes alveolar bone regeneration by promoting jaw bone marrow mesenchymal stem cells proliferation and differentiation via glycolysis pathway. . Cell Prolif. 2021; 54(7): e13058 doi: 10.1111/cpr.13058. DOI: https://doi.org/10.1111/cpr.13058

Ren Z, Machuca-Gayet I. Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption. PLOS ONE. 2015; 10(7): e0132513 doi: 10.1371/journal.pone.0132513. DOI: https://doi.org/10.1371/journal.pone.0132513

Bullitt EE. Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol. 1990; 296(4): 517-530. DOI: https://doi.org/10.1002/cne.902960402

Zhao Q, Wang X, Liu Y, He A, Jia R. NFATc1: Functions in osteoclasts. Int J Biochem Cell Biol. 2010; 42(5): 576–579. doi:10.1016/j.biocel.2009.12.018. DOI: https://doi.org/10.1016/j.biocel.2009.12.018

Khosla S, Westendorf J, Oursler M. Building bone to reverse osteoporosis and repair fractures. J Clin Invest. 2008; 118(2): 421–428. DOI: https://doi.org/10.1172/JCI33612

Rogers A, Saleh G, Hannon R, Greenfield G, Eastell R. Circulating estradiol and osteoprotegerina as determinants of bone turnover and bone density in postmenopausal women. J Clin Endocrinol Metab. 2002; 87: 4470-4475. DOI: https://doi.org/10.1210/jc.2002-020396

Wada T, Nakashima T, Hiroshi N, Penninger JM. RANKL–RANK signaling in osteoclastogenesis and bone disease. Trends in Molecular Medicine. 2006; 12(1): 17–25. doi:10.1016/j.molmed.2005.11.007. DOI: https://doi.org/10.1016/j.molmed.2005.11.007

Fujita S, Yamaguchi M, Utsunomiya T, Yamamoto H, Kasai K. Low-energy laser stimulates tooth movement velocity via expression of RANK and RANKL. Orthod Craniofac Res. 2008; 11(3): 143-155. doi: 10.1111/j.1601-6343.2008.00423.x. PMID: 18713151. DOI: https://doi.org/10.1111/j.1601-6343.2008.00423.x

Panwar P. A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K. British Journal of Pharmacology. 2015; 173(2): 396–410. doi:10.1111/bph.13383 . DOI: https://doi.org/10.1111/bph.13383

Hou W, Li W, Keyszer G, Weber E. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002; 46(3): 663-674. doi: 10.1002/art.10114. DOI: https://doi.org/10.1002/art.10114

Cheng T, Murphy C, Cantrill L. Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics. 2014; 38(7): 1527-1533. DOI: https://doi.org/10.1007/s00264-013-2255-0

Ren X. Highly selective azadipeptide nitrile inhibitors for cathepsin K: design, synthesis and activity assays. Org Biomol Chem. 2013; 11: 1143-1148. DOI: https://doi.org/10.1039/c2ob26624e

Suda T, Nakamura I, Jimi E, Takahashi N. Regulation of osteoclast function. J Bone Miner Res. 1997; 12(6): 869-879. DOI: https://doi.org/10.1359/jbmr.1997.12.6.869

Ventura-Orriols E, Biosca-Adzet C. Utilidad del propéptido amino-terminal del procolágeno tipo 1 (P1NP) como marcador de remodelado óseo en el paciente sometido a trasplante renal. Rev del Lab Clin. 2009; 2(2): 80-86. DOI: https://doi.org/10.1016/j.labcli.2008.11.005

Garlet G. Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints. J Dent Res. 2010; 89(12): 1349-1363. DOI: https://doi.org/10.1177/0022034510376402

Guo Y, Li Y, Xue L, Severino R, Gao S, Niu J. salvia miltiorrhiza: an ancient Chinese herbal medicine as a source for anti-osteoporotic drugs. J Ethnopharmacol. 2014; 155(3): 1401-1416. DOI: https://doi.org/10.1016/j.jep.2014.07.058

Wang C, Stashenko P. The role of interleukin-1 alpha in the pathogenesis of periapical bone destruction in a rat model system. Oral Microbiol Immunol. 1993; 8(1): 50-56. DOI: https://doi.org/10.1111/j.1399-302X.1993.tb00543.x