Comparación de la estimulación por microvibración versus inhibidores de catepsina K a nivel molecular y celular: una revisión sistemática

Yomira Salgado Martínez; Rosina Eugenia Villanueva Arriaga; Salvador García López; Nelly Molina Frechero

doi:10.30827/ars.v65i4.30321

Authors

Yomira Salgado Martínez Maestría en ciencias odontológicas, Ciudad de México. https://orcid.org/0000-0002-7161-4822
Rosina Eugenia Villanueva Arriaga Universidad Autónoma Metropolitana, Maestría en Ciencias Odontológicas, CDMX, Ciudad de México
Salvador García López Universidad Autónoma Metropolitana, Maestría en Ciencias Odontológicas, CDMX, Ciudad de México.
Nelly Molina Frechero Universidad Autónoma Metropolitana, Maestría en Ciencias Odontológicas, CDMX, Ciudad de México.

DOI:

https://doi.org/10.30827/ars.v65i4.30321

Keywords:

bone, osteoclast, osteoporosis, enzyme, cathepsin, treatment

Abstract

Introduction: Bone is constantly remodeling to maintain the structure of the bone tissue that composes it. This is susceptible to changes that can be both favorable and harmful, marked by certain variables such as age, sex, diseases, hormonal alterations, trauma, among others.

Method: Due to the above, the idea was raised to study which treatment is better in the regeneration of bone tissue, comparing pharmacological treatments (cathepsin K inhibitors) against micro-vibratory stimulation or non-pharmacological treatment.

Objective: To carry out a systematic review of treatments with microvibrations and cathepsin K inhibitors in relation to bone remodeling.To make a comparison between the effectiveness of treatment based on micro-vibrations and with cathepsin K inhibitors, a systematic review was carried out in nine databases (Wiley Online Library, Pubmed, Google Academic, Scopus, Science Direct, Scielo , Medline, EBSCO and SpringerLink).

Results: Twenty articles were included in this study, which demonstrated that both treatments improve the bone remodeling process.

Conclusions: Taking into consideration the systematic review carried out, it has been determined that the treatment of low-intensity, high-frequency micro-vibrations increases the outer cortex; however, the use of cathepsin k inhibitors promises innovative treatments in tissue regeneration.

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