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Abstract
We have described a method based on McDaniel's (8) for the determination of quinolinic acid in several animal tissues. The method consist in the extraction of quinolinic acid, selective adsortion on activated charco al and decarboxylation to nicotinic acid which have been measured by colorimetric reaction. With this method we have measured the concentrations of quinolinic acid in rat renal cortex after the tryptophan injection to rato We have found that anyone of values is enough to make an inhibition of phosphoenol pyruvate carboxykinase activity and t he renal gluconeogenic capacity.
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