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Abstract
The effect of exercise (swimming in water at 22° fur 2 hours) on rat liver and kidney glucose 6-phosphatase, fructose diphosphatase, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase activities and kidney phosphate-dependent glutaminase activity was studied. Exercise increases the activities of glucose 6-phosphatase (prevented by
previous treatment with bicarbonate), alanine aminotransferase and phosphate-dependent glutaminase in kidney and do es not affect the enzymic activities tested in liver. Glucose production from alanine by kidney cortical slices is not negligible despite the low activity of alanine aminotransferase and is also activated by exercise. These results do not preclude the key role of phosphoenolpyruvate carboxykinase activation during the metabolic adaptation of kidney to exercise but suggest additional points of regulations of gluconeogenesis in these conditions.
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