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The extended Hildebrand solubility approach is used to estimate the solubility of benzocaine in several solvent mixtures showing different polarity (water-ethanol, ethanol-ethyl acetate and ethyl acetate-hexane). The solubility profiles were well reproduced by use of extended Hildebrand solubility approach proposed by Martin et al .. Besides, a modification to this method was tested, which iñcludes a F lory-H uggins size correction term to account for different sizes of the solute and the solvento The third model studied directly relates the logarithm of mole fraction solubility to the solubility parameter. The maximum solubility for benzocaine appeared at a solubility parameter value 22.50 MPa112. With the third model, the calculated values are very close to the experimental values and it is adventageous because the molar heat and the temperature of fusion are not needed.
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