Estrogenic Xenobiotics: A goal for the Functional Toxicology
Keywords:
Organochlorine pesticides, Bisphenol-A, Chemicals pollutantsAbstract
Numerous compounds in dialy industrial, agricultural or domestic use ha ve estrogenic
effects. AIkylphenols, and sorne organochIorine pesticides have diverse chemical structures
and mimics estradiol-1713 in animals and in humans. For mots chemicals pollutants we
do not know whether they are estrogenic or not, what their effects are singly or together,
or even the degree of exposure. We propose a new toxicologic approach to the study of
these chemicals by whjch besides molecular structure and physicochernical properties
analysis they should be tested to identify functional activity in "in culture" assays as the
E-SCREEN for estrogenicity.
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