Changes induced by cholesterol and fatty acids on the perinatal evolution of chick HMG-CoA reductase

Authors

  • A. GIL-VILLARINO
  • M CASTILLO
  • P. LUQUE
  • j. IGLESIAS
  • E. GARCÍA-PEREGRIN

Keywords:

Cholesterol, HMG-CoA reductase, Coconut oil, Neonatal chick., Menhaden oil.

Abstract

The effect of dietary fat quality on cholesterol metabolism in neonatal chick was

examined in order to c1arify the dífferent mechanisms of hyper- and hypolipidemic action.

Diet supplementation with 10% coconut oil produced a significant hypercholesterolemia

after 7 days of treatment. Supplementation with 10% coconut oil plus 1% cholesterol

produced a very higher increase of plasma cholesterol levels (about 2-3 times higher

than those found with standard diet), while menhaden oil (10%) produced a significant

decrease of total cholesterol. Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase

did not change by coconut oil treatment. However, both coconut oil plus cholesterol

and menhaden oil supplemented diets drastically decreased reductase activity after I

week of dietary manipulation. Our results suggest that different mechanisms may be

implied in the regulation of cholesterol metabolism by the different fatty acids and/or

cholesterol, especially at the level of reductase activity.

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Published

1996-12-20

How to Cite

1.
GIL-VILLARINO A, CASTILLO M, LUQUE P, IGLESIAS j., GARCÍA-PEREGRIN E. Changes induced by cholesterol and fatty acids on the perinatal evolution of chick HMG-CoA reductase. Ars Pharm [Internet]. 1996 Dec. 20 [cited 2024 May 19];37(4):853-62. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21304

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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