Effect of congenital hypothyroidism on postnatal development of rat liver mitochondria

Authors

  • A. ALMEIDA
  • J.M. MEDINA

Abstract

 

The effects of congenital hypothyroidism on postnatal changes of rhodamine 123-

stained mitochondrial populations, respiratory function and osmotic activity of rat liver

mitochondria have been studied. Hypothyroidism prevented the postnatal increase in

the percentage of mitochondrial low fluorescence population (LFP, mature form) that

occurs immediately after birth. This effect coincides with the prevention of postnatal

onset of respiratory function and osmotic activity of liver mitochondria from hypothyroid

newboms. The administration of thyroid hormones to hypothyroid newboms at birth

reversed all these c::ffects, reaching levels of maturation similar to those of euthyroid

newboms. The effect of thyroid hormones on the percentage of mitochondrial populations

and on the functional (RCR) and structural (osmotic activity) maturation were prevented

by cycloheximide supplement. Our results suggest that thyroid hormones regulate

postnatal development of liver mitochondria through the synthesis of some(s) protein(s)

involved in the FO,FI-ATPase assembly.

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References

POLLAK, J. K.: Biochem J (1975), 150:477-488.
POLLAK, J. K., SUTTON, R.: Trends Biochem Sci (1980), 5:23-27.
ALMEIDA, A., LÓPEZ-MEDIAVILLA, C., ORFAO, A., MEDINA, J.: FEBS Lett (1994), 34 :50-54.
VALCARCE, C., NAVARRETE, R. M., ENCABO, P., LOECHES, E., SATRúSTEGUI,
J., CUEZ A J. M.: J Biol Chem (1988), 263:7767-7775.

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Published

1996-12-20

How to Cite

1.
ALMEIDA A, MEDINA J. Effect of congenital hypothyroidism on postnatal development of rat liver mitochondria. Ars Pharm [Internet]. 1996 Dec. 20 [cited 2024 May 19];37(4):807-16. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21301

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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