Influence of the thyroid status on the regulation of the IGFs/IGFBPs axis

Authors

  • S. RAMOS
  • A. M. PASCUAL-LEONE

Keywords:

IGFs, Thyroid

Abstract

A series of experiments have been performed in three populations of rats: neonates

(lO, 15 and 20-day-old rats), weanning (27, 32 and 37-day-old rats) and adult rats.

These animals were thyrectomized, tretaed with metimazol and sacrified after 5, 10 and

15 days of thyrectomy. Rats were subsequently recovered with 1,5 ¡¡g of tiroxin per 100

g of body weight in the case of neonates and 1,75 ¡¡g in the case of adults. The recovery

was al so made by pellet implantation. Circulating IGFs and IGFBPs were determined

as well as the express ion of hepatic rnRNA. It is concluded that the action of the

thyroid hormones on the IGF/IGFBP axis is age related. In addition, is concluded that

insulin may mediate the effect of thyroid hormones.

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Published

1999-12-20

How to Cite

1.
RAMOS S, PASCUAL-LEONE AM. Influence of the thyroid status on the regulation of the IGFs/IGFBPs axis. Ars Pharm [Internet]. 1999 Dec. 20 [cited 2024 Dec. 22];37(4):761-70. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21295

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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