Glycemia-reducing effects of Bolivian nutraceutical plants

Authors

  • Silvia Zambrana 1 Universidad Mayor de San Andrés, Facultad de Ciencias Farmacéuticas y Bioquímicas, Instituto de Investigaciones Fármaco Bioquímicas, Área de Farmacología, La Paz, Bolivia 2 Karolinska Institutet and Karolinska University Hospital, Department of Molecular Medicine and Surgery, 17176 Stockholm, Sweden
  • Orlando Mamani 1 Universidad Mayor de San Andrés, Facultad de Ciencias Farmacéuticas y Bioquímicas, Instituto de Investigaciones Fármaco Bioquímicas, Área de Farmacología, La Paz, Bolivia
  • Mabel Canaviri 1 Universidad Mayor de San Andrés, Facultad de Ciencias Farmacéuticas y Bioquímicas, Instituto de Investigaciones Fármaco Bioquímicas, Área de Farmacología, La Paz, Bolivia
  • María del Pilar Gutiérrez 1 Universidad Mayor de San Andrés, Facultad de Ciencias Farmacéuticas y Bioquímicas, Instituto de Investigaciones Fármaco Bioquímicas, Área de Farmacología, La Paz, Bolivia
  • Sergiu-Bogdan Catrina 2 Karolinska Institutet and Karolinska University Hospital, Department of Molecular Medicine and Surgery, 17176 Stockholm, Sweden 3 Karolinska University Hospital, Department of Endocrinology and Diabetes, 17176 Stockholm, Sweden 4 Center for Diabetes, Academic Specialist Centrum,11365 Stockholm, Sweden
  • Claes-Goran Ostenson 2 Karolinska Institutet and Karolinska University Hospital, Department of Molecular Medicine and Surgery, 17176 Stockholm, Sweden
  • Eduardo Gonzales 1 Universidad Mayor de San Andrés, Facultad de Ciencias Farmacéuticas y Bioquímicas, Instituto de Investigaciones Fármaco Bioquímicas, Área de Farmacología, La Paz, Bolivia

Keywords:

Nutraceutical, Natural product, Insulin secretion

Abstract

Introduction: The prevalence of diabetes type 2 is increasing worldwide, thus the search of novel alternative therapies is needed. According to their traditional use, we selected five Bolivian plants Chenopodium quinoa (CQ) Amaranthus caudatus (AC), Chenopodium pallidicaule (CP), Lupinus mutabilis (LM) and Smallanthus sonchifolius (SS) that are traditionally used to control glycemia.

Methods: The effect of a single oral administration of Ethanolic (EtOH), hydro-ethanolic (EtOH70) and aqueous (Aq) extracts from all plant species were tested for their effect on blood glucose in non-fasted mice and during the oral glucose tolerance test (OGTT). The effect on insulin secretion was evaluated in mice pancreatic islets.

Results: EtOH70 extracts of all the plants showed glucose-reducing effect at the highest dose evaluated (2000 mg/kg b.w.). EtOH70 extracts improved the glucose tolerance evaluated by the OGTT in mice fasted for 12 hours. The extracts have different effects on glucose homeostasis since just extracts of AC, LM and CQ but not CP and SS increased insulin secretion as shown on mice pancreatic islets. The phytochemical qualitative characterization of EtOH70 extracts detected phenolic acids and flavonoids in AC, CP and CQ; alkaloids in LM and anthocyanidins in SS. None of EtOH70 extracts tested showed in vitro or in vivo acute toxicity at concentrations where they exhibit glucose lowering effects.

Conclusions: We report here that extracts from AC, CQ, CP, LM and SS exhibit glucose lowering effect while just AC, CQ and LM stimulate directly the insulin secretion.

 

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Author Biography

Silvia Zambrana, 1 Universidad Mayor de San Andrés, Facultad de Ciencias Farmacéuticas y Bioquímicas, Instituto de Investigaciones Fármaco Bioquímicas, Área de Farmacología, La Paz, Bolivia 2 Karolinska Institutet and Karolinska University Hospital, Department of Molecular Medicine and Surgery, 17176 Stockholm, Sweden

Docente Investigador. Área de Farmacología, Instituto de Investigaciones Fármaco Bioquímicas. Facultad de Ciencias Farmacéuticas y Bioquímicas. Universidad Mayor de San Andrés

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Published

2020-12-20

How to Cite

1.
Zambrana S, Mamani O, Canaviri M, Gutiérrez M del P, Catrina S-B, Ostenson C-G, Gonzales E. Glycemia-reducing effects of Bolivian nutraceutical plants. Ars Pharm [Internet]. 2020 Dec. 20 [cited 2024 Aug. 24];62(1):52-65. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/15456

Issue

Vol. 62 No. 1 (2021)

Section

Original Articles

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Copyright (c) 2020 Silvia Zambrana, Orlando Mamani, Mabel Canaviri, María del Pilar Gutiérrez, Sergiu-Bogdan Catrina, Claes-Goran Ostenson, Eduardo Gonzales

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