Bioactivity of umbelliprenin, the major component found in the seeds of Angelica sylvestris

Authors

  • SD SARKER School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, N. Ireland, UK
  • L NAHAR School of Life Sciences, The Robert Gordon University, St. Andrew Street, Aberdeen AB25 1HG, Scotland, UK
  • MM RAHMAN Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
  • M SIAKALIMA School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK
  • M MIDDLETON School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK
  • M BYRES School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK
  • Y KUMARASAMY School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK
  • E MURPHY School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK

Keywords:

Angelica sylvestris, Apiaceae, Antioxidant activity, Antibacterial activity, Brine shrimp lethality bioassay

Abstract

Umbelliprenin (1), a sesquiterpenyl coumarin, isolated as the major component present in the n-hexaneand dichloromethane extracts of the seeds of Angelica sylvestris (Apiaceae), has been assessed forantibacterial and antioxidant activities. General toxicity of 1 has also been evaluated by the brine shrimplethality (BSL) bioassay

Downloads

Download data is not yet available.

References

Clapham AR, Tutin TG and Warburg EF. Flora of the British Isles. 1952. Cambridge University Press, UK.

USDA-ARS-GRIN Database. USDA, ARS, National Genetic Resources Program, Germplasm Resources Information

Network - (GRIN), National Germplasm Resources Laboratory, Beltsville, Maryland, USA. 2004. Available on-line at http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?3425

Howard M. Traditional Folk remedies Comprehensive Herbal. 1987. London: Century Hutchinson Ltd.

Sarker SD and Nahar L. Natural medicine: the genus Angelica. Current Medicinal Chemistry 2004. 11: 1479-1500.

Potterton D. Couplers’ Colour Herbal. 1997. Cippenham: Foulsham Publishing.

Sarker SD, Eynon E, Fok K, Kumarasamy Y, Murphy EM, Nahar L, Shaheen EM, Shaw NM and Siakalima M. Screening the extracts of the seeds of Achillea millefolium, Angelica sylvestris and Phleum pratense for antibacterial, antioxidant activities and general toxicity. Oriental Pharmacy and Experimental Medicine. 2003. 3: 157-162.

Murphy EM, Nahar L, Byres M, Shoeb M, Siakalima M, Rahman MM, Gray AI and Sarker, SD. Coumarins from the seeds of Angelica sylvestris (Apiaceae) and their distribution within the genus Angelica. Biochem. Syst. Ecol. 2004. 32, 203-207.

Kumarasamy Y, Nahar L, Byres M, Delazar A and Sarker, SD. Assessment of biological activities associated with the major constituents of the methanol extract of ‘wild carrot’ (Daucus carota L.) seeds. J. Herbal Pharmacotherapy. 2005.

in press).

Rahman MM, Sarker SD, Byres M and Gray AI. New salicylic acid and isoflavone derivatives from Flemingia paniculata. J. Nat. Prod. 2004. 67: 402-406.

Delazar A, Byres M, Gibbons S, Kumarasamy Y, Nahar L, Modarresi M, Shoeb M and Sarker SD. Iridoid glycosides from Eromostachys glabra. J. Nat. Prod. 2004. 67: 1584-1587

Datta BK, Datta SK, Chowdhury MM, Khan TH, Kundu JK, Rashid MA, Nahar L and Sarker SD. Analgesic, antiinflammatory and CNS depressant activities of sesquiterpenes and a flavonoid glycoside from Polygonum viscosum. Die Pharmazie. 2004. 59: 222-225.

Shoeb M, Rahman MM, Nahar L, Jaspars M, MacManus S, Delazar A and Sarker SD. Bioactive lignans from the seeds of Centaurea macrocephala. DARU. 2004. 12:87-93.

Kumarasamy Y, Byres M, Cox PJ, Delazar A, Jaspars M, Nahar L, Shoeb M and Sarker, SD. Isolation, structure elucidation and biological activity of flavone C-glycosides from the seeds of Alliaria petiolata. Chemistry of Natural Compounds. 2004. 40: 122-128.

Haque ME, Haque M, Rahman MM, Rahman MM, Khondkar P, Wahed MII, Mossadik MA, Gray AI and Sarker SD. E-Octadec-8-en-5-ynoic acid from the roots of Capparis zeylanica. Fitoterapia. 2004. 75: 130-133.

Sarker SD, Kumarasamy Y and Nahar L. Insect sex pheromone type alkenes from the seeds of Quercus robur (Fagaceae).

Chemistry of Natural Compounds. 2004. 40: 286-288.

Datta BK, Khan TH, Kundu JK, Rashid MA, Datta SK, Nahar L and Sarker SD. Anti-cholinergic, cytotoxic and anti-HIV-1 activities of sesquiterpenes and a flavonoid from Polygonum viscosum. Pharm. Biol. 2004. 42: 18-23.

Uddin SJ, Shilpi JA, Delazar A, Nahar L and Sarker SD. Free radical scavenging activity of some Bangladeshi plant extracts. Oriental Pharmacy and Experimental Medicine. 2004. 4: 185-193.

Takao T, Watanabe N, Yagi I and Sakata K. A simple screening method for antioxidants and isolation of several antioxidants produced by marine-bacteria from fish and shellfish. Biosci. Biotech.Biochem. 1994. 58: 1780-1783.

Meyer BN, Ferrigni NR, Putnam JE, Jacobson LB, Nicholas DE, McLaughlin JL. Brine shrimp - a convenient general bioassay for active-plant constituents. Planta Medica. 1982. 45:31-34.

Finney DJ. Probit Analysis, 3rd edn, Cambridge University Press Cambridge. (1971).

Dadak V, Hodak K. Some relations between the structure and the antibacterial activity of natural coumarins. Experientia. 1966. 22:38-39.

Zboril P, Holasova J, Dadak V. Antibiotic efficiency of natural coumarins. X. Mode of action of phenolic derivatives of coumarin on succinate oxidase in the Keilin-Hartree preparation. Collection of Czechoslovak Chemical Communications. 1970. 35: 2983-2995.

Ngwendson JN, Badir E, Efange SMN, Okunji CO, Iwu MM, Schuster BG, Khan IA. Constituents of Peucedanum zenkeri seeds and their antimicrobial effects. Die Pharmazie. 2003. 58: 587-589.

Iranshahi M, Shahverdi AR, Mirjani R, Amin G, Shafiee A. Umbelliprenin from Ferula persica roots inhibits the red pigment production in Serratia marcescens. Journal of Bioscience. 2004. 59: 506-508.

Published

2004-12-20

How to Cite

1.
SARKER S, NAHAR L, RAHMAN M, SIAKALIMA M, MIDDLETON M, BYRES M, KUMARASAMY Y, MURPHY E. Bioactivity of umbelliprenin, the major component found in the seeds of Angelica sylvestris. Ars Pharm [Internet]. 2004 Dec. 20 [cited 2025 Apr. 2];46(1):35-41. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5062

Issue

Section

Original Articles