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Abstract
The long-term and short-term effects of chronic metabolic acidosis and experimental diabetes on the PPC dehidrogenases activities have been investigated. The ingestion of 0.28 M ammonium chloride solution produced and increase in the G6PDH y 6PGDH activities about 90% and 60%, at day seven, either saturate or subsaturate substrate concentration. The alloxan induce diabetes (200 mg/Kg body weight) produced a significant increase of G6PDH and 6PGDH around 100 and 40% respectively, at both saturating or subsaturating substrate concentrations. Nevertheless, no significant changes were found during the short time periods. Also, during these pathological situations not significant variations were found in the Km values for G6PDH and 6PGDH. The nature of these increases and its relationship with the renal hipertrophy and cellular proliferation have been discussed.
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