Bran of cassava starch flour and bran of cassava flour as potential tablet excipients
DOI:
https://doi.org/10.30827/ars.v60i4.9385Keywords:
excipient, tablets, Manihot esculentaAbstract
Objectives: The physicochemical characteristics of bran of cassava starch flour and bran of cassava flour (viz. organoleptic characteristics, pH value, moisture content, total ashes, lipid, protein, starch and fiber contents) and biopharmacotechnical parameters (viz. granulometry, flow capacity, angle at rest, outflow time and apparent density) were evaluated aiming at assessing their potential use as tablet excipients.
Methodos: Three tablet formulations of venlafaxine hydrochloride were proposed, having as excipients bran of cassava flour, bran of cassava starch flour and Starch 1500®. The tablets were produced using two different pressures (98±5 MPa and 32±6 Mpa) and their mechanical (hardness and friability) and dissolubility characteristics were evaluated.
Results and Conclusions: The tablets produced with both cassava flours, using higher pressures, presented similar physicochemical characteristics to those obtained with the excipient Starch1500®, thus indicating that cassava flours possess the potential to be used as disintegrating agents in tablets.
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Verma S, Baghotia A, Singh J, Saroha K , Kumar S, Kumar D. Pharmaceutical excipients: A regulatory aspect. Pharma Innov J. 2016; 5(6): 124-7
Angiolucci T, Oliveira Jr J M, Chaud M V, Aranha N, Andréo Filho N. Study of physical-chemical properties involved in the compaction process of an experimental formulation containing zidovudine. Rev Ciênc Farm Básica Apl. 2012; 33(2): 233-43.
Abrantes CG, Duarte D, Reis CP. An overview of pharmaceutical excipients: safe or not safe? J Pharma Sci. 2016; 105(7): 2019-26. doi.org/10.1016/j.xphs.2016.03.019
Aulton ME. Delineamento de formas farmacêuticas, 2nd ed. Porto Alegre: Artemed; 2005.
Builders PF, Arhewoh, M. Pharmaceutical applications of native starch in conventional drug delivery. Starch 2016; 68(9-10):864-73. doi.org/10.1002/star.201500337
Allen Jr LV, Popovich NG, Ansel HC. Formas farmacêuticas e sistemas de liberação de fármacos, 9nd ed. Porto Alegre: Artmed; 2013.
Barreto LCLS, Cunha-Filho MSSC. Co-processed excipients for direct compression tablets. Lat Am J Pharm. 2009; 28 (2): 304-12.
Chitedze J, Monjerezi M, Saka JDK, Steenkamp J. Binding effect of cassava starches on the compression and mechanical properties of ibuprofen tablets. J Appl Pharm Sci. 2012; 2 (4): 31-37. doi: 10.7324/JAPS.2012.2402
Ogaji I J, Nep EI, Audu-Peter JD. Advances in natural polymers as pharmaceutical excipients. Pharm Anal Acta. 2012; 3(1): 146-61. doi: 10.4172/2153-2435.1000146
Odeku OA. Potentials of tropical starches as pharmaceutical excipients: a review. Starch. 2013; 65 (1-2): 89-106. doi.org/10.1002/star.201200076
Castro AD, Bueno JHF. Aplicação do farelo de mandioca como desintegrante em comprimido. In: Ereda MP, editor. Culturas de tuberosas amiláceas latino americanas. São Paulo: Fundação Cargill; 2002.
Brazilian Pharmacopoeia, 5 nd ed. Brasília: Anvisa; 2010. p.614-5.
Instituto Adolfo Lutz. Normas analíticas do Instituto Adolfo Lutz. Métodos químicos e físicos para análise de alimentos. 4nd ed. São Paulo: Instituto Adolfo Lutz; 2010, p. 83-158.
Allem Jr LV, Popovich NG, Ansel HC. Ansel’s pharmaceutical forms and drug delivery systems, 11nd ed. Philadelphia:Wolters Kluwer; 2017.
Oliveira Jr JM, Chaud MV, Aranha N. Orsi VC, Lima Jr JR, Andréo Filho N. Design, construction and performance of an instrumented press machine for study of densification processes of pharmaceutics forms. Rev Bras Farm. 2012; 93(1): 91-101
Tzanavaras PD, Verdoukas A, Themelis DG. Development and valitadion of a flow-injection assay for dissolution studies of the anti-depressant drug venlafaxine. Anal Sci. 2005; (21): 1515-8.
United States Pharmacopoeia 30. The National Formulary 25. Rockville: United States Pharmacopeial Convention; 2007.
Portuguese Pharmacopoeia, 9nd ed, Lisboa: Infarmed; 2008.
Rowe R C, Sheskey P J, Quinn M E. Handbook of pharmaceutical excipients, 6 nd ed, London: PhP Pharmaceutical Press; 2009.
Cereda, M. P. Caracterização dos Resíduos da Industrialização da mandioca. In: Cereda, MP, editor. Industrialização da mandioca no Brasil. São Paulo: Paulicéia; 1994, p. 11-50.
Lachman L, Lieberman HA, Kaning JLT. Teoria e prática na indústria farmacêutica, 3nd ed. Lisboa: Fundação Calouste Guldenkian; 2015.
Markl D, Zeitler JA. A review of disintegration mechanisms and measurement techniques. Pharm Res. 2017; 34(5): 890–917. doi: 10.1007/s11095-017-2129-z
Patel S, Kaushal AM, Bansal A K. Compression physics in the formulation development of tablets. Crit Rev Ther Drug Carrier Syst. 2006; 23(1):1-65. doi: 10.1615/CritRevTherDrugCarrierSyst.v23.i1.10
Monica RPR, Shilpa HJ, Swati ST, Vaishali SK. Desing and pharmacodymanic evaluation of optimized microporous tablets of vanlafaxine hydrochoride. Indian J Pharm Sci. 2017; 79 (2): 241-9. doi: 10.4172/pharmaceutical-sciences.1000222
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Copyright (c) 2019 Valéria Campos Orsi, Marta Maria Duarte Carvalho Vila, Valquiria M. Hanai-Yoshida, Marco V. Chaud, Victor M. Balcão, José M. Oliveira Jr.
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