Performance Evaluation of Maize Starch as a Multifunctional Excipient in Metronidazole Tablet Formulation

Authors

  • Yonni Eshovo Apeji Ahmadu Bello University, Zaria, Nigeria
  • Abdulhakim Ali Ahmadu Bello University, Zaria
  • Sophie Nock Anyebe Ahmadu Bello University, Zaria
  • Oluwaseun Adenike Orugun Kaduna State University, Kaduna State
  • Adeniji Kehinde Olowosulu Ahmadu Bello University, Zaria
  • Avosuahi Rukayat Oyi Ahmadu Bello University, Zaria

DOI:

https://doi.org/10.30827/ars.v60i3.9289

Keywords:

Maize starch, multifunctional excipient, granules, tableting

Abstract

Objective: The aim of this study was to evaluate the performance of maize starch as a multifunctional excipient in metronidazole tablet formulation.

Methods: Metronidazole tablets were prepared by wet granulation containing maize starch as diluent (40 %), disintegrant (10 %), and binder (5 %) and compared with a reference formulation containing lactose as diluent (40 %), maize starch as disintegrant (10 %) and acacia as binder (5 %). The granules were analysed for particle size, flow properties, compressibility and moisture content. Tablets weighing 500 mg were compressed for both formulations on a Single Punch Tablet Press using a 12 mm flat-faced punches at 57.5 MPa. The tablets were kept for 24 h to allow for elastic recovery and evaluated for weight and content uniformity, thickness, crushing strength, friability, disintegration time and in vitro drug release.

Results: The granule properties revealed differences in mean granule size, angle of repose, bulk and tapped densities for both formulations. Batch I tablets gave rise to better tableting properties compared to batch II tablets.

Conclusion: This study confirms the suitability of maize starch as a multifunctional excipient in tablet formulation.

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Author Biographies

Yonni Eshovo Apeji, Ahmadu Bello University, Zaria, Nigeria

Department of Pharmaceutics and Industrial Pharmacy/ Senior Lecturer

Abdulhakim Ali, Ahmadu Bello University, Zaria

Pharmaceutics and Industrial Pharmacy

Sophie Nock Anyebe, Ahmadu Bello University, Zaria

Pharmaceutics and Industrial Pharmacy / Lecturer I

Oluwaseun Adenike Orugun, Kaduna State University, Kaduna State

Pharmaceutics and Industrial Pharmacy / Lecturer II

Adeniji Kehinde Olowosulu, Ahmadu Bello University, Zaria

Pharmaceutics and Industrial Pharmacy / Reader

Avosuahi Rukayat Oyi, Ahmadu Bello University, Zaria

Pharmaceutics and Industrial Pharmacy / Professor

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Published

2019-09-20

How to Cite

1.
Apeji YE, Ali A, Anyebe SN, Orugun OA, Olowosulu AK, Oyi AR. Performance Evaluation of Maize Starch as a Multifunctional Excipient in Metronidazole Tablet Formulation. Ars Pharm [Internet]. 2019 Sep. 20 [cited 2025 Jul. 30];60(3):161-7. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/9289

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Original Articles