Proliposomas: Una aproximación para el desarrollo de liposoma estables

Autores/as

  • Namita Singh Integral University. Faculty of Pharmacy, Lucknow
  • Poonam Kushwaha Integral University. Faculty of Pharmacy, Lucknow
  • Usama Ahmad Integral University. Faculty of Pharmacy, Lucknow
  • Mohammad Abdullah Integral University. Faculty of Pharmacy, Lucknow

DOI:

https://doi.org/10.30827/ars.v60i4.8517

Palabras clave:

Liposoma, Proliposoma, Estabilidad, Biodisponibilidad, Fosfolipido, Colesterol

Resumen

Antecedentes: durante varios años, se han realizado muchos intentos para mejorar la estabilidad liposomal. En 1986, Payne et al, introdujeron el concepto de pro-liposoma para la preparación de liposoma con el fin de evitar la inestabilidad fisicoquímica encontrada en algunas suspensiones de liposoma tales como agregación, fusión, hidrólisis, y/o oxidación.

Objetivo: el objetivo de esta revisión es centrarse en diferentes aspectos relacionados con los Proliposomas, su método de preparación, técnicas de caracterización, asi como señalar su alcance en los sistemas de administración de fármacos.

Métodos: los Proliposomas son una nueva forma de sistemas de administración de fármacos. Son productos granulares secos y de flujo libre compuestos por fármacos y fosfolípidos que, al añaderse el agua, se dispersan para formar una suspensión liposomal multilamelar.

Resultados y discusión: estos Proliposomas son casi tan buenos o quizás mejores que los liposomas convencionales. En la presente revisión se explica brevemente el concepto de Proliposomas con un enfoque en sus componentes, preparación, caracterizaciones y su campo de aplicación.

Conclusión: una extensa encuesta de literaturas y datos recogidos sugiere que los pro-liposomas son portadores de fármacos prometedores para el futuro.

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Citas

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Publicado

2019-12-20

Cómo citar

1.
Singh N, Kushwaha P, Ahmad U, Abdullah M. Proliposomas: Una aproximación para el desarrollo de liposoma estables. Ars Pharm [Internet]. 20 de diciembre de 2019 [citado 29 de marzo de 2024];60(4):231-40. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/8517

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