Toxicidad de xenobióticos mediada por radicales libres de oxígeno

Authors

  • M MARTÍNEZ-CAYUELA Departamento de Bioquímica y Biología Molecular. Polígono Universitario de Cartuja, s/n. Universidad de Granada. Granada 18071. España.

Keywords:

Ciclo redox, Radicales libres de oxígeno, Toxicidad de xenobióticos

Abstract

La toxicidad de muchos xenobióticos está mediada por la formación de radicales libres de oxígeno. Estos xenobióticos son reducidos por un electrón produciendo especies químicas que reaccionan con el oxígeno molecular (O2) para dar lugar a radiculaes anión superóxido (O2) y regenerar la molécula original. De este modo se crea un ciclo redox que implican un gran consumo de O2 y de equivalentes redox, principalmente en forma de NADPH. Los radicales libres producidos durante este ciclo redox, así como las especies reactivas derivadas de él, serían los responsables del daño celular causado por dichos xenobióticos.

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References

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Published

1997-12-20

How to Cite

1.
MARTÍNEZ-CAYUELA M. Toxicidad de xenobióticos mediada por radicales libres de oxígeno. Ars Pharm [Internet]. 1997 Dec. 20 [cited 2025 Jul. 8];39(1):05-18. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5991

Issue

Vol. 39 No. 1 (1998)

Section

Review Articles

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