Influencia de los tensides en la liberación de las sustancias medicinales de los geles hidrófilos: influencia del polisorbato 20 y polisorbato 80 en la liberación del hidrocortisona de los geles hidrófilos
Keywords:
Hidrogeles, Propilenglicol - 1, 2, PEG 200, Polisorbato 20, Polisorbato 80, HidrocortisonaAbstract
El proceso de liberación de hidrocortisona de los hidrogeles con la adición del 1% y del 3% del polisorbato 20o polisorbato 80, en la presencia de propilenglicol - 1,2 o PEG 200, tiene dos fases. Durante la primera fase lasvelocidades de liberación son más altas, comparando con la segunda fase. La segunda fase de liberación correspondea la cinética de primer orden. Los periodos de semiliberación en el transcurso de esta fase oscilan entre15,67 y 23,50.Downloads
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