First experiences of monitoring of vancomycin in a General Hospital of Specialties

Authors

  • Félix Gómez-De Rueda Servicio de Farmacia Hospitalaria, Complejo Hospitalario de Jaén
  • Inmaculada Elsegui Horno Servicio de Farmacia Hospitalaria, Complejo Hospitalario de Jaén
  • Mª Eugenia Tena-Sempere Servicio de Oftalmología, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla
  • Alicia Gómez-Rodríguez Servicio de Oftalmología, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla
  • Mª José Rodriguez Sanz Subdirección de Enfermería, Complejo Hospitalario de Jaén
  • Florentina Horno-Ureña Servicio de Farmacia Hospitalaria, Complejo Hospitalario de Jaén

DOI:

https://doi.org/10.30827/ars.v57i4.5558

Keywords:

vancomycin, monitoring, clinical pharmacokinetics

Abstract

Introduction: vancomycin is an effective antibiotic for the treatment of infections due to Gram-positive germs, however renal toxicity associated with its use, has relegated its use to use secondary lines. This fact has consolidated the empirical treatment with more expensive antibiotics.

Objective: to analyze the data of monitoring of vancomycin and rating the efficiency facing the use of other antibiotics.

Materials and methods: observational study where discusses monitoring pharmacokinetics of Vancomycin and a unit of pharmacokinetics clinical efficiency, with a population of 137 patients admitted to a general hospital specialties.

Results: the use of Vancomycin in first intention meant a savings of € 16.472,82 regarding the use of € 83.039,83 the linezolid and daptomycin. However, 18% of our sample not could be treated with Vancomycin, making it necessary to have other drugs.

Downloads

Download data is not yet available.

References

Walsh T, Howe RA. The prevalence and mechanisms of vancomycin resistance in Staphylococcus aureus. Annu Rev Microbiol 2002; 56:657-75.

Lowy FD. Antimicrobial Resistance: the example of Staphylococcus aureus. The Journal of Clinical Investigation 2003; 111(9):1265-73.

Elyasi S, Khalili H, Dashti-Khavidaki S, Mohammadpour A. Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors and special populations. A literature review. Eur J Clin Pharmacol. 2012; 68(9):1243–55.

Weston A, Golan Y, Holcroft C, Snydman DR. The efficacy of daptomycin versus vancomycin for methicillin-resistant Staphylococcus aureus bloodstream infection in patients with impaired renal function.

Clin Infect Dis. 2014; 58(11):1533-1539.

Stephen Y. Lianga, Hani N. Khaira, Jay R. McDonalda,b, Hilary M. Babcocka, and Jonas Marschall. Daptomycin vs. vancomycin for osteoarticular infections due to methicillin-resistant Staphylococcus aureus (MRSA): A nested case-control study. Eur J Clin Microbiol Infect Dis. 2014; 33(4): 659–664.

Kim HB, Lee YS, Kim BS, Cha JO, Kwon SU, Lee HJ, Suh JT, Rheem I, Kim JM, Shin BM, Kim MN, Lee K, Lee CS, Kim EC, Oh MD, Choe KW. Prevalence and clinical implications of Staphylococcus aureus with a vancomycin MIC of 4 microg/ml in Korea. Microb Drug Resist 2006; 12(1):33-8.

Appelbaum PC. The emergence of vancomycin-intermediate and vancomycinresistant Staphylococcus aureus. Clin Microbiol Infect 2006; 12(1):16-23.

Goldstein FW, Kitzis MD. Vancomycin-resistant Staphylococcus aureus: no apocalypse now. Clin Microbiol Infect 2003; 9:761-5.

Rybak MJ, Akins RL. Emergence of methicillin-resistant Staphylococcus aureus with intermediate glycopeptide resistance: clinical significance and treatment options. Drugs 2001; 61(1):1-7.

Published

2016-12-20

How to Cite

1.
Gómez-De Rueda F, Elsegui Horno I, Tena-Sempere ME, Gómez-Rodríguez A, Rodriguez Sanz MJ, Horno-Ureña F. First experiences of monitoring of vancomycin in a General Hospital of Specialties. Ars Pharm [Internet]. 2016 Dec. 20 [cited 2024 Jul. 22];57(4):177-81. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5558

Issue

Section

Original Articles