Development and Evaluation of Isoniazid Loaded Silk Fibroin Microsphere

Authors

  • Narinder Singh Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Surya Prakash Gautam Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Harjaskaran Harjaskaran Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Amanjot Amanjot Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Lovepreet Singh Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Ankit Verma Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Shalu Rani Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.

DOI:

https://doi.org/10.30827/ars.v57i3.5331

Keywords:

silk fibroin, nanoformulation, biodegradability, isoniazid

Abstract

Aim: Current experimental investigation is dedicated to prepare microspheres with small size and good sphericity by Phase Separation method using Isoniazid (INH) as model drug. Silk fibroin has unique intrinsic qualities like biodegradability, biocompatibility or release properties and their tunable drug loading capacity. The delivery loading proficiency of the drug molecules in silk spheres be contingent on their charge, and hydrophobicity or subsequent in altered drug release profiles.

Methods: In the present work Isoniazid loaded silk fibroin microsphere was prepared by using phase separation method. Microsphere was evaluated for Ultraviolet-visible spectroscopy, Fourier Transform infrared spectroscopy, Entrapment efficiency, Scanning electron microscopy Studies.

Results: Scanning electron microscopy studies revealed that Isoniazid Loaded Silk Fibroin Microspheres were spherical. Entrapment Efficiency of Isoniazid loaded Microspheres of different Formulation from F1 to F5 was in range of 53 to 68 %. F3 showed 68.47 % entrapment Efficiency and the optimized formulation drug release was 93.56 % at 24 hours.

Conclusion: Experimental report disclosed a new aqueous based formulation method for silk spheres with controllable shape or size and sphere. Isoniazid loaded silk microspheres may act as ideal nano formulation with elaborated studies.

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References

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Published

2016-09-20

How to Cite

1.
Singh N, Gautam SP, Harjaskaran H, Amanjot A, Singh L, Verma A, Rani S. Development and Evaluation of Isoniazid Loaded Silk Fibroin Microsphere. Ars Pharm [Internet]. 2016 Sep. 20 [cited 2024 Aug. 24];57(3):137-42. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5331

Issue

Vol. 57 No. 3 (2016)

Section

Original Articles

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