The kinetic study of dediazoniation in an aqueous medium of benzenediazonium tetraflourborate

Authors

  • B QUINTERO Dpto. Química Física. Facultad de Farmacia. Universidad de Granada
  • M.C CABEZA Dpto. Química Física. Facultad de Farmacia. Universidad de Granada
  • M.I MARTINEZ-PUENTEDURA Dpto. Química Física. Facultad de Farmacia. Universidad de Granada
  • P GUTIÉRREZ Dpto. Química Física. Facultad de Farmacia. Universidad de Granada
  • P.J MARTÍNEZ Dpto. Química Física. Facultad de Farmacia. Universidad de Granada
  • J LLOPIS Dpto. Fisiología. Facultad de Farmacia. Universidad de Granada
  • A ZARZUELO Dpto. Farmacología. Facultad de Farmacia. Universidad de Granada

Keywords:

Aryl cation, kinetics, Genotoxic compounds, Dediazoniation, HPLC, Benzenediazonium ion, Dediazoniation mechanism

Abstract

The kinetic analyses carried out at different temperatures (20ºC - 40ºC) indicate that the dediazoniation process of thebenzenediazonium ion (BZ) is of the order of one, with BZ at A = 2,3.1015 s-1 and Ea = 112,5 kJ.mol-1 for the Arrheniusequation, and ΔH‡ = 110,0 kJ.mol-1 and ΔS‡ = 40,7 J.K-1.mol-1 for the Eyring equation. The chromatographic resultsreveal that BZ decomposes through a heterolytic process mediated by the aryl ion. The presence of Cu(I) or Cu(II) saltsand ascorbic acid produce a change in the reaction mechanism. The intermediate compounds produced in these conditionsare stable species that may be transported in the bloodstream. The model studied suggests a possible explanation for thelocalisation of tumours produced by the administration of BZ in rats.

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Published

2003-06-16

How to Cite

1.
QUINTERO B, CABEZA M, MARTINEZ-PUENTEDURA M, GUTIÉRREZ P, MARTÍNEZ P, LLOPIS J, ZARZUELO A. The kinetic study of dediazoniation in an aqueous medium of benzenediazonium tetraflourborate. Ars Pharm [Internet]. 2003 Jun. 16 [cited 2024 Jul. 22];44(3):239-55. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5153

Issue

Vol. 44 No. 3 (2003)

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