Alginate microspheres for dermatopharmaceutical use
Keywords:
All-trans-retinoic acid, Tretinoin, Vitamin A acid, Dermatopharmacy, Microspheres, Salicylic acid, Sodium alginateAbstract
Simple and reproducible methods were developed to microencapsulate all-trans-retinoic acid (RA) and salicylic acid (SA)in solution. The objectives of the present study were to improve their therapeutic applications and to establish comparativecriteria concerning the different methodologies that have been used. The objective of RA and SA microencapsulationon the one hand, is to modulate AR release in an attempt to protect skin from AR and AS irritation and, on the other,is to protect RA from environmental hazards such as air, light and moisture.Downloads
References
AHFS Drug Information. Tretinoin. p.3449. Editor American Society of Health-System Pharmacists, Inc. Bethesda 2002.
European Pharmacopoeia. 3th edition, supplement, p.1533. Council of Europe, France 2001.
Ezpeleta I, Irache JM, Stainmesse S, Chabenat C, Gueguen J, Popineau Y et al. Gliadin nanoparticles for the controlled
release of all-trans-retinoic acid. Int. J. Pharm. 1995; 131: 191-200.
Gilman AG, Goodman LS, Rall TW, Murad F. Las Bases Farmacológicas de la Terapéutica. 7º edición. Buenos Aires:
Ed. Médica Panamericana, 1986.
Gombotz WR, Wee SF. Protein release from alginate matrices. Advanced Drug Delivery Reviews 1998; 31: 267-285.
Griffiths WAD, Wilkinson JD. Topical Therapy. En: Champion RH, Burton JL, Burns DA, editors. Textbook of Dermatology.
London: Blackwell Science, 1998; p.3556.
Kang S, Voorhees JJ. Topical Retinoids. En: Fitzpatrick´s. Ed.: Freedberg IM , Eisen AZ, Wolff K, editors. Dermatology
in General Medicine. New York: Mc.Graw-Hill, 1999; p.2726-2733.
Marcus R, Coulston AM. Retinoic acid. En: Goodman & Gilman´s. The Pharmacological Basis of Therapeutics. Hardman
JG, Limbird LE, editors. New York: Mc.Graw-Hill, 2001; p.1781.
Roehl EL. Stability tests for emulsions. Soap. Perfum. Cosm. 1972; 45: 343-350.
Skov MJ, Quigley JW, Bucks DAW. Topical Delivery System for Tretinoin: Research and Clinical Implications. J.
Pharm. Sci. 1997; 86(10): 1138-1143.
The United States Pharmacopoeia. 25th edition, p.1739-1741. The United States Pharmacopoeial Convention, Inc.,
Rockville, MD, 2002.
The United States Pharmacopoeia. Drug Information for the Health Care Professional. 20th edition, p. 3046. Micromedex,
Vila Jato JL. Tecnología Farmacéutica. Madrid: Síntesis, 1997.
You JO, Park SB, Park HY, Haam S, Chung CH, Kim WS. Preparation of regular sized Ca-alginate microspheres using
membrane emulsification method. J. Microencapsulation 2001; 18(4): 521-532
Downloads
Published
How to Cite
Issue
Section
License
The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:
- The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.
b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.
c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).