Preparation and Physicochemical characterisation of caprylocapryl macrogol -8- glycerides microemulsion for oral drug delivery

Authors

  • PK GHOSH Drug Delivery Research Laboratory, Pharmacy Department, The M.S. University of Baroda, Vadodara, India
  • ML UMRETHIA Drug Delivery Research Laboratory, Pharmacy Department, The M.S. University of Baroda, Vadodara, India
  • RJ MAJITHIYA Drug Delivery Research Laboratory, Pharmacy Department, The M.S. University of Baroda, Vadodara, India
  • RSR MURTHY Professor in Pharmaceutics, Drug Delivery Research Laboratory, GH Patel Pharmacy Building, Donor’s Plaza, Opposite to M.S. University Office, Fatehgunj, Vadodara-390002, Gujarat, India

Keywords:

Electroconductivity, Interfacial tension, Particle size, Microemulsion, Non-ionic surfactant

Abstract

The performance of caprylocapryl macrogol -8- glycerides in the development of pharmaceutically acceptable, stable, selfemulsifyingmicroemulsion was assessed. The suitability of the concentration of surfactant with respect to the oil phasewas assessed by interfacial tension measurement. A pseudoternary microemulsion system was constructed using caprylocaprylmacrogol -8- glycerides / polyglyceryl 6-dioleate / medium chain triglycerides and water. The model microemulsion wascharacterised with regard to its electroconductive behaviour and droplet size measurement after dilution with water aswell as with simulated gastric fluid, surface charge, centrifugal stability, viscosity and stability studies. The percolationtransition theory, which makes it possible to determine the percolation threshold and to identify the bicontinuousstructures, was applied to the system. The interfacial tension changes associated with the microemulsion formation showsultra low values upto 30% oil at a surfactant / cosurfactant ratio 4:1. Moreover, the investigated particle size after dilutionwith excess of water as well as with simulated gastric fluid proved the efficiency of the microemulsion system as a potentialcarrier for oral drug delivery.

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Published

2004-09-20

How to Cite

1.
GHOSH P, UMRETHIA M, MAJITHIYA R, MURTHY R. Preparation and Physicochemical characterisation of caprylocapryl macrogol -8- glycerides microemulsion for oral drug delivery. Ars Pharm [Internet]. 2004 Sep. 20 [cited 2024 May 17];45(4):335-41. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5120

Issue

Vol. 45 No. 4 (2004)

Section

Original Articles

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