Effect of methanol extract of Achyranthes aspera linn. On rifampicininduced hepatotoxicity in rats

Authors

  • AR BAFNA Departamento de Farmacia, Facultad de Tecnología e Ingeniería, The M.S.University of Baroda, Baroda -390 001, Gujarat, INDIA.
  • SH MISHRA Departamento de Farmacia, Facultad de Tecnología e Ingeniería, The M.S.University of Baroda, Baroda -390 001, Gujarat, INDIA.

Keywords:

Achyranthes aspera, Hepatotoxicity, Rifampicin

Abstract

Methanol extract of aerial parts of Achyranthes aspera Linn. (Family: Amaranthaceae) was tested for its effect onrifampicin-induced hepatotoxicity in albino rats at five dose levels. Rifampicin intoxication in rats significantly (p < 0.001)elevated the levels of SGPT, SGOT, ALKP, and total bilirubin, which indicated acute hepatocellular, damage and biliaryobstruction. Methanol extract showed dose dependent decrease in the levels of SGPT, SGOT, ALKP and total bilirubin.Minimum effective dose of extract was found to be 100 mg/kg body weight. Results obtained from histopathological studiesalso supported hepatoprotective activity of drug against rifampicin induced hepatotoxicity. Thus study demonstrates thatA. aspera possess anti-hepatotoxic effect against rifampicin.

Downloads

Download data is not yet available.

References

Venkateswaran S, Pari L, Viswanathan P, Menon VP. Protective effect of Livex, a herbal formulation against erythromycin estolate-induced hepatotoxicity in rats. J. Ethnopharmacol. 1997; 57: 161-167.

Latha U, Rajesh MG, Latha MS. Hepatoprotective effect of an ayurvedic medicine. Ind. Drugs 1999; 36: 470-473.

Mitra SK, Seshadri SJ, Venkataranganna MV, Gopumadhavan S, Venkatesh Udupa U, Sarma DNK. Effect of HD-03-a herbal formulation in galactosamine-induced hepatopathy in rats. Ind. J. Physiol. Pharmacol. 2000; 44: 82-86.

Dhuley JN, Naik SR. Protective effect of Rhinax, a herbal formulation against CCl4-induced liver injury and survival in rats. J. Ethnopharmacol. 1997; 56: 159-164.

Parthasarathy R, Raghupati Sarma G, Janardhanam B,Ramachandran P, Santha T, Sivasubramanian S. Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and

pyrazinamide. Tubercle 1986; 67: 99-108

Shakun NP and Tabachuk OP. The comparative action of isoniazide, rifampicin and ethambutol on liver function. Eksp. Klin. Farmakol. 1992; 55: 45.

Nadkarni KM and Nadkarni AK. Indian Materia Medica 1976; Vol.I, 3rd Edition, Popular Prakashan Pvt. Ltd., Bombay, Page-21.

Ram AK, Bhagwat AW, Gupta SS. Effect of the saponin of Achyranthes aspera on the phosphorylase activity of rat heart. Ind. J Physiol Pharmacol. 1971; 15(3): 107-10.

Akhtar MS, Iqbal J. Evaluation of the hypoglycaemic effect of Achyranthes aspera in normal and alloxan-diabetic rabbits.

J. Ethnopharmacol. 1991; 31(1): 49-57.

Pakrashi A, Bhattacharya N. Abortifacient principle of Achyranthes aspera Linn. Ind. J. Exp Biol. 1977 Oct; 15(10):856-858.

Bhaumik A, Sharma MC. Therapeutic effect of two herbal preparations in induced hepatopathy in sheep. J. Res. Edu. Ind. Med. 1993; 12 (1): 33-42.

Kokate, C.K. Text book of Practical Pharmacognosy 1996; second edition, Pragati prakashan. Pune.

Kurma SR, Mishra SH. Effect of rhizomes of Curculigo orchioides Gaertn. on drug induced hepatotoxicity. Ind. Drugs 1996; 33:458-461.

Harper HA. The functions and tests of the liver, In: Review of physiological chemistry. Los Altos, California: Lange Medical Publishers, 1961: 271-283.

Drotman RB, Lawhorn GT. Serum enzymes as indicators of chemical induced liver damage. Drug Chem. Toxicol. 1978; 1: 163-171.

Rao RR. Mechanism of drug induced hepatotoxicity. Ind. J. Pharmacol. 1973; 5: 313-318.

Singh B, Saxena AK, Chandan BK, Anand KK, Suri OP, Suri KA, Satti NK. Hepatoprotective activity of verbenalin on experimental liver damage in rodents. Fitoterapia 1998; 69: 135-140.

Bowman WC, Rand MJ. In: Text Book of Pharmacology 1982; 2nd ed. Oxford, London: Blackwell Scientific Publications, 34-39.

Downloads

Published

2004-09-20

How to Cite

1.
BAFNA A, MISHRA S. Effect of methanol extract of Achyranthes aspera linn. On rifampicininduced hepatotoxicity in rats. Ars Pharm [Internet]. 2004 Sep. 20 [cited 2024 May 17];45(4):343-51. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5119

Issue

Vol. 45 No. 4 (2004)

Section

Original Articles

License

The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:

  1. The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.

b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.

c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).