Analysis of simvastatin in pharmaceutical preparations by high performance thin layer chromatography

Authors

  • SN MEYYANATHAN Dept. de Química Farmacéutica, J.S.S. College of Pharmacy, Ootacamund – 643 001, Tamilnadu, India
  • GVS RAMASARMA Dept. de Química Farmacéutica, J.S.S. College of Pharmacy, Ootacamund – 643 001, Tamilnadu, India
  • B SURESH Dept. de Química Farmacéutica, J.S.S. College of Pharmacy, Ootacamund – 643 001, Tamilnadu, India

Keywords:

HPTLC, Simvastatin, Fexofenadine, Tablets

Abstract

A new simple, precise, rapid, and selective high-performance thin layer chromatography (HPTLC) method has beendeveloped for the analysis of simvastatin in pharmaceutical preparations. The method uses fexofenadine as an internalstandard. The stationary phase was silica gel 60 F254 prewashed with methanol; ethyl acetate - methanol - ammoniasolution 25% (7:1.5:0.5, v/v) was used as mobile phase. Detection and quantification were performed densitometricallyat λ = 220nm. The linear range of the analysis was 0.08 - 0.8 μg and the percentage recovery was 100.7 %.

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References

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Published

2004-03-20

How to Cite

1.
MEYYANATHAN S, RAMASARMA G, SURESH B. Analysis of simvastatin in pharmaceutical preparations by high performance thin layer chromatography. Ars Pharm [Internet]. 2004 Mar. 20 [cited 2024 Jul. 22];45(2):121-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5108

Issue

Vol. 45 No. 2 (2004)

Section

Original Articles

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