UVA-induced loss of quinolone antibacterial activity

Authors

  • E FERNÁNDEZ Facultad de Farmacia, Casilla 5001-V, Valparaíso, Chile
  • G SÁNCHEZ Facultad de Farmacia, Casilla 5001-V, Valparaíso, Chile
  • E NAVARRETE Facultad de Farmacia, Casilla 5001-V, Valparaíso, Chile
  • F DEL ALCÁZAR Facultad de Farmacia, Casilla 5001-V, Valparaíso, Chile

Keywords:

Quinolones, Photolysis, MIC, Photodegradation

Abstract

The antibacterial activity of UVA-irradiated solutions of nalidixic acid, ciprofloxacin and levofloxacin was investigated.Photolysis of quinolones produced a decrease in antibacterial activity in strains of E. coli and S. aureus, becomingmanifest through an increase of 50% in the minimum inhibitory concentration of the drug as compared to nonirradiatedquinolones. In this study, it is suggested that a radical-mediated photolytic mechanism exists, leading to thephotodegradation of the γ-piridone-β-carboxylic group, which is the mediator that is responsible for the drugs antibacterialactivity

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Published

2004-03-20

How to Cite

1.
FERNÁNDEZ E, SÁNCHEZ G, NAVARRETE E, DEL ALCÁZAR F. UVA-induced loss of quinolone antibacterial activity. Ars Pharm [Internet]. 2004 Mar. 20 [cited 2024 Jul. 22];45(2):111-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5107

Issue

Vol. 45 No. 2 (2004)

Section

Original Articles

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