Analysis of the influence of hydration of the epidermis on the bio-mechanical behaviour of in vivo skin
Keywords:
Epidermis, Bio-mechanics, Hydration, In vivoAbstract
The Bio-mechanical properties of in vivo human skin are important indicators of a healthy skin condition, with regardto functional organisation. It seems that these properties do not only arise from the cutaneous structures themselves, butalso from the contribution of underlying tissues. Consequently, in the study of its behaviour a purely biomechanicalapproach cannot be taken. Furthermore, the technological systems used the in vivo assessment of these properties,cannot provide a direct measurement of the biophysical characteristics of the organ, due to the fact that it is not possibleto quantitatively identify the relative contribution of each tissue. The variables and parameters obtained as such, shouldtherefore, be considered as mechanical “descriptors”, meaning that greater care should be taken in the interpretationof the results. For this reason, one of the most relevant questions concerning these properties concerns the relativecontribution of the epidermis to the biomechanical behaviour of the entire organ .Facing such multiple complexities, the present protocol was designed to approach this last question. Two differenttreatments (water only and glycerine solution at 10%), inducing epidermal water equilibrium changes, were applied tohealthy volunteers and the respective biological response was recorded. The Results seem to indicate that the mechanicalbehaviour of human skin can be modified and eventually modulated by topical interventions, suggesting that theepidermis may influence the global bio-mechanical behaviour of the entire human skin.Downloads
References
Rodrigues L. , A avaliação biofísica da superfície cutânea: Indicadores fisiológicos da funcionalidade epidérmica, Rev. Port. Farm. ,Vol. XLV, nº 1, 16-23, 1995
Piérard, G and the EEMCO Group, EEMCO guidance to the in vivo Assessment of tensile functional properties of the skin: Part 1, Skin Pharmacol Appl Skin Physiol 12:352-362, 1999
Rodrigues L. , A avaliação biofísica da superfície cutânea: princípios e metodologias, Rev. Port. Farm. ,Vol. XLV, nº 2, p 48, 1995
Rodrigues L and the EEMCO Group. EEMCO guidance to the in vivo Assessment of tensile functional properties of the skin: Part 2, Skin Pharmacol Appl Skin Physiol;14: 52-67, 2001
Jemec G.B.E. , Serup, J., Epidermal hydration and skin mechanics. The relationship between electrical capacitance and the mechanical properties of human skin in vivo, Acta Derm. Venereol (Stochk), 70: 245;1990.
Piérard GE, Mechanical properties of aged skin: Indentation and Elevation experiments, in JL Lévèque & P.Agache Eds. “Aging Skin”, Marcel Dekker Inc., Ch.5; 1993
Barel A. O. , Courage W. ,Clarys P. , Suction Method for Measurement of skin Mechanical Proprietes : The Cutometer. Handbook of Non-Invasive Methods of the Skin, J.Serup & G.B.E.Jemec Eds, CRC Press, Ch. 3 : pp. 335-340, 1995
Rodrigues L., “The in vivo Biomechanical Testing of the skin and the cosmetological efficacy claim support - A critical overview”, in “Cosmetics – Controlled Efficacy Studies and Regulation” P. Elsner,H.F.Merk & H.Maibach Eds., Springer-Verlag Berlin, Heidelberg, Ch.16: 197-208, 1999
Overgaard Olsen L. , Jemec G. B. E. , The Influence of Water, Glycerin, Paraffin Oil and Ethanol on Skin Mechanics, Acta Derm. Venereol (Stochk), 73: 404-406; 1993
Wickett R.R. , Murray B.C., Sensitivity of cutometer data to stratum corneum hydration level, Skin Research and Technology , 2: 167-172; 1996.
Rogiers, V. Balls, M., Basketter, D., Berardesca, E., Edwards, C., Elsner, P., Ennen, J., Lévèque, J.L., Loden, M., Masson, Ph., Parra, J.L., Paye, M., Piérard, G.E, Rodrigues, L., Schaeffer, H., Salter, D., Zuang, V., The Potencial use of Non-invasive methods in the safety assessment of cosmetic products: The Report and Recommendations of a ECVAM/EEMCO Workshop, ATLA 27, 515-537, 1999
Auriol, F., Vaillant, L. , Machet, L. , Diridollou, S. , Lorette, G., Effects of Short-time Hydration on Skin Extensibility, Acta Derm. Venereol (Stochk), 73: 344-347; 1993.
Wickett R.R. , Murray B.C., Correlations between Dermal Torque Meter, Cutometer, and Dermal Phase Meter measurements of human skin, Skin Research and Technology 1997, 3: 101-106; 1997.
Rodrigues, L.M., Minhós, R., Pinto, P.C., Lamarão, P., Significado Fisiológico da Avaliação Biomecânica do Tecido Cutâneo in vivo por Método de Sucção (“Cutometria”), Trab. Soc. Port. Dermatol. Venereol., 60 (4): 21-32, 2002.
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