Antioxidant activity of activit, a herbomineral formulation, in experimentally induced cardiac and renal damage

Authors

  • A PALLAVI Pharmacy Department, Faculty of Technology and Engineering, The M.S.University of Baroda, Baroda -390 001, Gujarat, INDIA.
  • R BALARAMAN Pharmacy Department, Faculty of Technology and Engineering, The M.S.University of Baroda, Baroda -390 001, Gujarat, INDIA.

Keywords:

Antioxidant, Catalase, Cisplatin, Isoproterenol, Lipid peroxidation, Reduced glutathione, Superoxide dismutase

Abstract

Activit, a herbomineral formulation, was administered orally to rats at the dose levels of 125, 250, 500 and 1000 mg kg-1 to investigate its effect on isoproterenol-induced myocardial infarction and cisplatin-induced renal damage. The drugreduced the levels of serum creatine kinase (CK), glutamic oxaloacetate transaminase (GOT), lactate dehydrogenase(LDH) and uric acid in isoproterenol-induced cardiac damage. In cisplatin-induced renal damage, Activit reduced theserum levels of creatinine, urea, blood urea nitrogen (BUN) and uric acid. It was further found that administration ofActivit increased the levels of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and membranebound enzymes like Ca2+ATPase, Mg2+ATPase and Na+K+ATPase and decreased lipid peroxidation (MDA) in heart andkidney in isoproterenol-induced myocardial necrosis and cisplatin-induced renal damage, respectively. Thus it can beconcluded that Activit possesses antioxidant activity and by virtue of this action it can protect the heart and kidney fromdamage caused by isoproterenol and cisplatin, respectively.

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Published

2003-12-20

How to Cite

1.
PALLAVI A, BALARAMAN R. Antioxidant activity of activit, a herbomineral formulation, in experimentally induced cardiac and renal damage. Ars Pharm [Internet]. 2003 Dec. 20 [cited 2024 Dec. 22];45(1):45-57. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5099

Issue

Vol. 45 No. 1 (2004)

Section

Original Articles

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