Biodegradable microspheres of poly(D,L-lactide) containing progesterone
Keywords:
Biodegradable microspheres, Factorial design, D, L-PLA, Progesterone, Sustained releaseAbstract
Microspheres of poly(D,L-lactide) containing progesterone were prepared by the solvent evaporationmethod using a simple oil water emulsion. 23 factorial design was used to determine the effect of threeindependent variables (amount of drug, amount of polymer and concentration of polyvinyl alcohol) overthe dependent variables (drug content and particle size). The three independent variables influencedsignificantly over the percentage drug encapsulated. On the other hand, in the particle size case, thevariables which produced a significantly influence were the polyvinyl alcohol concentration and theamount of polymer. The in vitro release studies have shown that according to the particle size, it canbe obtained formulations which are able to release progesterone in a few days or a sustained releaseamong 28 days. The physical state of drug has been examined by differential scanning calorimetric. Thestudies indicate that exists a physicochemical interaction between the progesterone and the polymer.Downloads
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