Studies for evaluation of body iron

Authors

  • M ROQUE Laboratorio de Fisiología Humana. Departamento de Biología, Bioquímica y Farmacia. Universidad Nacional del Sur. Bahía Blanca. Argentina
  • C GATTI Laboratorio de Fisiología Humana. Departamento de Biología, Bioquímica y Farmacia. Universidad Nacional del Sur. Bahía Blanca. Argentina
  • M AGGIO Laboratorio de Fisiología Humana. Departamento de Biología, Bioquímica y Farmacia. Universidad Nacional del Sur. Bahía Blanca. Argentina

Keywords:

Ferritin, Iron deficiency anemia, Healthy subjects, Soluble transferrin receptor

Abstract

Objetive: Multi-parameter studies combining serum Transferrin Receptor (sTfR) with Ferritin, hemoglobin,transferrin saturation percentage for an assessment of iron status. Materials and Methods.Subjects:Healthy Adults (HA)(n=51) and Iron-Deficient Anemic Patients (IDAP) (n=50). sTfR and Ferritin weremeasured by ELISA. Results: Mean confidence interval IC95(μ) showed that the mean value for sTfRwas 15.5-18.1 nmol/L (95% probability) in HA group. In IDAP both the sTfR mv and range (66.3 nmol/L, 16.1-148.4 nmol/L, (α) 0.05), and the sTfR/F Index (75.8) were greater than in HA (5% significancelevel). TfR/Hb (p<0.001), 71% (r2), and Ferritin/Hb (p<0.001), 70 % (r2), showed that for Hb <120g/L, sTfR is more sensitive than Ferritin. sTfR/Ferritin (p<0.001), 72% (r2) showed significant sTfRincreases for ferritins <12μg/L. Conclusion: Our studies confirm that the sTfR detects iron-sensitivechanges with a diagnostic accuracy. The combined use of sTfR and conventional parameters allows foreasier iron status assessment.

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Published

2005-03-20

How to Cite

1.
ROQUE M, GATTI C, AGGIO M. Studies for evaluation of body iron. Ars Pharm [Internet]. 2005 Mar. 20 [cited 2025 Jun. 20];46(2):181-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5074

Issue

Vol. 46 No. 2 (2005)

Section

Original Articles

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