An efficient and versatile synthesis of new Trojan-horse cephalosporins

Authors

  • A SPAGGIARI Dipartimento di Chimica, Università di Modena e Reggio Emilia, via Campi, 183 – 41100 Modena (Italia)
  • LC BLASZCZAK Discovery Chemistry Research and Technologies, Lilly Corporate Center, Eli Lilly and Co., Indianápolis, Indiana 46285 (EE. UU.)
  • F PRATI Dipartimento di Chimica, Università di Modena e Reggio Emilia, via Campi, 183 – 41100 Modena (Italia)

Keywords:

Trojan-horse, Cephalosporin, Quinolone, β-lactam, AmpC, Antibiotics

Abstract

A useful synthesis of new dual-action cephalosporins is reported. These molecules could represent afascinating tool for treatment of bacterial infectious diseases, since they display a possible inhibitoractivity towards β-lactamase-expressing bacteria. The major advantage of this 3-step synthetic approachlies in its versatility, which allows the systematic preparation of a wide pool of new molecules.

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References

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Published

2005-03-20

How to Cite

1.
SPAGGIARI A, BLASZCZAK L, PRATI F. An efficient and versatile synthesis of new Trojan-horse cephalosporins. Ars Pharm [Internet]. 2005 Mar. 20 [cited 2024 May 21];46(2):167-80. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5073

Issue

Vol. 46 No. 2 (2005)

Section

Original Articles

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