Quality control of organochlorine biocide residues in fructus from Silybum marianum L.

Authors

  • D OBRESHKOVA Universidad Médica de Sofía, Facultad de Farmacia, Departamento de Química Farmacéutica
  • I PENCHEVA Universidad Médica de Sofía, Facultad de Farmacia, Departamento de Química Farmacéutica

Keywords:

Carsil, DDT, Fructus from Silybum marianum, L., Gas chromatography, Organochlorine biocides

Abstract

Analytical studies of organochlorine biocides show that their concentration in the plants (roots) is higherthan in the ground and particularly in the medicinal plants used in the therapy and the pharmacyindustry. The most favorite Bulgarian drugs (Carsil, Tribestan and Nivalin) contain plant extracts andthey have to be analyzed in respect to European Community Directives EEC/76/895 and EEC/90/6421998;In view of that the gas chromatography method for quantitative determination of organochlorine biocides(HCH and isomers, DDT and metabolites) was studied. Plant material from different regions of Bulgaria(fructus from Silybum marianum, L) and Carsil dragee produced by Sopharma Ltd. were analyzed inrespect to European Pharmacopoeia regulations. The method was validated and analytical parametersspecificity, linearity, precision, repeatability and range were studied.

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References

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Published

2005-03-20

How to Cite

1.
OBRESHKOVA D, PENCHEVA I. Quality control of organochlorine biocide residues in fructus from Silybum marianum L. Ars Pharm [Internet]. 2005 Mar. 20 [cited 2024 May 21];46(2):159-66. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5069

Issue

Vol. 46 No. 2 (2005)

Section

Original Articles

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