Polyethylene glycol as a de-aggregating agent in the preparation of celecoxib loaded gelatin microspheres

Authors

  • H THAKKAR Drug Delivery Laboratory, Centre of Relevance and excellence in NDDS, Pharmacy Department
  • RSR MURTHY Drug Delivery Laboratory, Centre of Relevance and excellence in NDDS, Pharmacy Department

Keywords:

De-aggregating agent, Gelatin microspheres, Poly-ethylene glycol

Abstract

Gelatin microspheres with high entrapment efficiency were prepared using emulsification chemical crosslinkingmethod using polyethylene glycol as a de-aggregating agent. Two different cross-linking agentsviz. formaldehyde and glutaraldehyde were used for cross-linking gelatin. The prepared microsphereswere characterized for entrapment efficiency, particles size, in-vitro drug release and the morphologywas studied by scanning electron microscopy. The FTIR studies indicated that there is no chemicalinteraction between gelatin and PEG. PEG acts only as a barrier to the aggregation of the gelatinmicrodrops present in the internal phase of the emulsion, while preparation. In-vitro drug release studiesindicated that the microspheres cross-linked using glutaraldehyde showed slower release rate than thosecross-linked with formaldehyde. Burst release was observed in both the cases. In general, about 40%of the drug is released in the first hour followed by a slow release for about 96 hours for glutaraldehydecross-linked microspheres.

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References

Álvarez A and Porta M. Pharmacoepidemiology in practice: current status and future trends. Drug Saf 1995; 13: 1-7.

Boxtel CJ and Wang G. Some observations on pharmacoepidemiology in Europe. Nether J Med 1997; 51: 205-12.

Strom BL and Carson JL. Use of automated database for pharmacoepidemiology research. Epidemiol Rev 1990; 12: 87-

Bador P and Petit O. Facteur d’impact et indexation dans les bases de donnéss bibliographiques: comparaison de ces deux

critères de qualité pour l’évaluation des revues pharmaceutiques. J Pharm Belg 1998; 53: 71-80.

López JM and Terrada ML. Los indicadores bibliométricos y la evaluación de la actividad médico-científica (III). Los

indicadores de producción, circulación, dispersión, consumo de la información y repercusión. Med Clin (Barc) 1992;

: 142-8.

Baños J, Bosch F, Bigorra J y Guardiola E. Difusión internacional de los ensayos clínicos realizados en España. Un análisis

a través de su publicación en revistas científicas. Med Clin (Barc) 1994; 102: 441-5.

Lewison G y Devey ME. Bibliometric methods for the evaluation of arthritis research. Rheumatology 1999; 38: 13-20.

Bordons M, Barrigan S y Méndez A. La investigación española en revistas internacionales de farmacia y farmacología

en el período 1980-1989. Med Clin (Barc) 1996; 106: 51-9.

López F, Boya J, Marín F y Calvo SL. Scientific research on the pineal gland and melatonin: a bibliometric study for

the period 1966-1994. J Pineal Res 1996; 20: 115-24.

Bador P, Picard A and Lochert F. Survey of European pharmaceutical journals in circulation in 1993. J Pharm Belg 1994;

: 409-32.

Villar J. El inglés, idioma internacional en Medicina. Med Clin (Barc) 1988; 91: 23-4.

Camí J, Zuleta MA, Fernández MT, Bordons M y Gómez I. Producción científica española en biomedicina y ciencias de la salud durante el período 1990-1993 (Science Citation Index y Social Science Citation Index) y comparación con el período 1986-1989. Med Clin (Barc) 1997; 109: 481-96.

Guardiola E and Baños JE. Presence of abstracts in non-English journals indexed in MEDLINE (1981-1990). Bull Med Libr Assoc 1993; 81: 320-2.

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How to Cite

1.
THAKKAR H, MURTHY R. Polyethylene glycol as a de-aggregating agent in the preparation of celecoxib loaded gelatin microspheres. Ars Pharm [Internet]. [cited 2024 May 19];46(1):19-34. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5061

Issue

Vol. 46 No. 1 (2005)

Section

Original Articles

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