Efectos del extracto de té verde sobre los daños oxidativos inducidos por cisplatino en riñones y testículos de ratas
Palabras clave:
Antioxidante, Cisplatino, Radicales libres, Té verde, Nefrotoxicidad, Toxicidad testicularResumen
Se administró extracto de té verde (Camellia sinensis) por vía oral a las ratas en dosis de 25, 50 y 100mg/kg para investigar sus efectos sobre la nefrotoxicidad y la toxicidad testicular inducida por cisplatino(3mg/kg). El extracto de té verde restauró el nivel de creatinina, urea, nitrógeno ureico en sangre (NUS)y ácido úrico en el suero de animales tratados con cisplatino en comparación con los animales tratadossólo con cisplatino. Además, se observó que la administración de extracto de té verde restauró losniveles de enzimas antioxidantes como superóxido dismutasa (SOD), catalasa (CAT) y glutatión reducido(GSH), y enzimas ligadas a la membrana como Na+K+ATPasa, Ca2+ATPasa y Mg2+ATPasa y redujo laperoxidación lipídica (MDA) en los riñones y en los testículos de animales con alteraciones tras eltratamiento crónico con cisplatino. Por tanto, se puede concluir que el extracto de té verde poseeactividad antioxidante y que, en virtud de esta acción, puede proteger los riñones y los testículos frentea los daños oxidativos inducidos por el cisplatino.Descargas
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