Bioactivity of the extracts and the isolation of lignans from the seeds of Centaurea dealbata

Authors

  • M JASPARS Marine Natural Products Laboratory, Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen, Aberdeen AB24 3UE, Escocia, Reino Unido
  • SM MACMANUS School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Escocia, Reino Unido
  • M SHOEB School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Escocia, Reino Unido
  • PK THOO-LIN School of Life Sciences, The Robert Gordon University, Aberdeen, Escocia, Reino Unido
  • SD SARKER School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Irlanda del Norte, Reino Unido
  • S CELIK Department of Biology, Faculty of Science and Literature, Canakkale 18 Mart University, 17020 Canakkale, Turquía

Keywords:

Centaurea dealbata, Asteraceae, Brine Shrimp Lethality Assay, DPPH, Antioxidant, Lignan

Abstract

Centaurea dealbata Willd. (Family: Asteraceae) belongs to the big genus Centaurea that comprises ca. 500 species. Then-hexane, dichloromethane (DCM) and methanol (MeOH) extracts of the seeds of C. dealbata have been assessed forantioxidant activity and general toxicity using, respectively, the DPPH assay, and the brine shrimp lethality assay. Boththe DCM and the MeOH extract showed signifi cant levels of antioxidant activities with an RC50 value 6.8 x 10-2 and4.7 x 10-2 mg/mL, respectively. None of the extracts exhibited any signifi cant general toxicity (LD50 = >1000 mg/mL).Three major bioactive components of the MeOH extract were found to be the lignans, arctigenin, arctiin and matairesinoside.The structures of these lignans were elucidated by comprehensive spectroscopic analyses, and also by directcomparison with the respective published data. This is the fi rst report on the occurrence of arctiin and matairesionl inC. dealbata. The distribution of these lignans within the genus Centaurea has also been presented.

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References

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Published

2006-12-20

How to Cite

1.
JASPARS M, MACMANUS S, SHOEB M, THOO-LIN P, SARKER S, CELIK S. Bioactivity of the extracts and the isolation of lignans from the seeds of Centaurea dealbata. Ars Pharm [Internet]. 2006 Dec. 20 [cited 2024 May 18];47(4):417-24. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/5042

Issue

Vol. 47 No. 4 (2006)

Section

Original Articles

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