Medicinal plants from Argentina with gastro protective activity

Authors

  • A BUCCIARELLI Laboratorio de Farmacognosia, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, (8000) Bahía Blanca, Argentina
  • MI SKLIAR Laboratorio de Farmacognosia, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, (8000) Bahía Blanca, Argentina

Keywords:

Gastro protection, Medicinal plants, Peptic ulcer

Abstract

The gastro protective activity of aqueous extracts from 11 plants native to Argentina was evaluated on ethanol-inducedgastric ulcer model in mice: Aloysia gratissima, Artemisia annua, Calendula offi cinalis, Gaillardia megapotamica,Maytenus ilicifolia, Parthenium hysterophorus, Portulaca oleracea, Rumex obtusifolius, Solanum eleagnifolium,Solidago chilensis and Spartium junceum. The results were expressed in terms of an Ulcer Index (UI), based on themeasurement of the length of the gastric lesions produced. Pharmacological assays demonstrated that aqueous extractsfrom all the plants, administered in oral form, showed signifi cant antiulcerogenic activity (P < 0.01). It has already beenestablished that among other compounds, the fl avonoids possess, gastro protective properties. As some of the aqueousextracts contain these constituents, the partial antiulcer activity found could be attributed to their presence. The mechanisminvolved in this effect has not been entirely elucidated and as a fi rst stage in its analysis, extracts should befractionated in order to better determine the role of each component.

Downloads

Download data is not yet available.

References

Sáinz R, Borda F, Domínguez E, Gisbert JP. Helicobacter pylori infection. Rev Esp Enfer Dig 1999; 91: 777-784.

Ohsugi M, Basnet P, Kadota S, et al. Traditional Medicines 1997; 14: 186-191.

Yesilada E, Sezik E, Fujita T, Tanaka S, Tabata M. Screening of some Turkish medicinal plants for their antiulcerogenic activities. Phytother Res 1993; 7: 263-265.

Toso RE, Skliar MI. Efecto citoprotector de extractos de Centaurea solstitialis sobre lesiones gástricas inducidas por estrés en ratas. Ciencia Veterinaria 1999; 1: 9-14.

Alvarez A, Pomar F, Sevilla MA, Montero MJ. Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip. J Ethnopharmacol 1999; 67: 333-340.

Giordano OS, Guerreiro E, Pestchanker MJ. The gastric cytoprotective effect of several sesquiterpene lactones. J Nat Prod 1990; 53: 803-809.

Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1979; 77: 433-443.

Alarcón de la Lastra C, Martín MJ, Motilva V. Antiulcer and gastroprotective effect of quercetin. A gross and hystologic

study. Pharmacology 1994; 48: 56-63.

Izzo AA, Di Carlo G, Mascolo N, Capasso F, Autore G. Antiulcer effect of flavonoids. Role of endogenous PAF. Phytother Res 1994; 8: 179-181.

Martín MJ, Marhuenda E, Pérez-Guerrero C, Franco JM. Antiulcer effect of naringin on gastric lesions induced by ethanol in rats. Pharmacology 1994; 49: 144-150.

Motilva V, Alarcón de la Lastra C, Martín MJ. Ulcer-protecting effects of naringenin on gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. J Pharm Pharmacol 1994; 46: 91-94.

Geissman TA. The chemistry of flavonoids compounds. Editorial Pergamon Press, Oxford, Gran Bretaña; 1962: pp. 72-76.

Shinoda J. Color reactions of flavone and flavonol derivatives and the like. J Pharm Soc Jpn 1928; 48: 214-220.

Bucciarelli A, Mancini MM, Skliar MI. Gastroprotective activity of Solidago chilensis. Bol Latinoam Caribe Plant Med Aromaticas 2007; 6: 332-333.

Dharmani P, Mishra PK, Maurya R, Chauhan VS, Palit G. Allophylus serratus: A plant with potential anti-ulcerogenic activity. J Ethnopharmacol 2005; 99: 361–366.

Salim AS. Removing oxygen-derived free radicals stimulates healing of ethanol-induced erosive gastritis in the rat. Digestion 1990; 47: 24-28.

Robert A, Nezamis AE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins. Gastroenterology 1979; 77: 761-767.

Borrelli F, Izzo AA. The plant kingdom as a source of antiulcer remedies. Phytother Res 2000; 14: 581-591.

Silen W. Experimental models of gastric ulceration and injury. Am J Physiol 1988; 255: G395-G402.

Downloads

Published

2007-12-20

How to Cite

1.
BUCCIARELLI A, SKLIAR M. Medicinal plants from Argentina with gastro protective activity. Ars Pharm [Internet]. 2007 Dec. 20 [cited 2024 Jul. 22];48(4):361-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4999

Issue

Vol. 48 No. 4 (2007)

Section

Original Articles

License

The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:

  1. The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.

b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.

c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).