Phytopharmacological screening of Luffa acutangula fruits for its antihepatotoxic activity

Authors

  • A MUKERJEE Department of Pharmacy, BBDNITM, Lucknow, U.P., India
  • G KAITHWAS Department of Pharmaceutical Sciences, F.H.M.S, Allahabad Agricultural Institute-Deemed University, Allahabad, U.P., India
  • PKS VISEN Department of Pharmacology, Central Drug Research Institute, Lucknow, U.P., India
  • SA SARAF Department of Pharmacy, BBDNITM, Lucknow, U.P., India

Keywords:

Luffa acutangula, Carbon tetrachloride, Paracetamol, Hepatoprotective, Silymarin

Abstract

The ethanolic and aqueous extract (100mg/kg) of Luffa acutangula Linn(fruits) was examined for antihepatotoxic activityin druckrey rats by inducing hepatotoxicity with Carbon tetrachloride(CCl4) and Paracetamol(PCM). The extracthas shown to posses signifi cant hepatoprotective effect by lowering the serum level of transaminases (SGPT & SGOT),Alkaline phosphatase (ALP) and bilirubin. The signifi cant hepatoprotective activity of Luffa acutangula is comparableto that standard hepatoprotective agent silymarin, which justify its use in liver affection.

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Published

2007-12-20

How to Cite

1.
MUKERJEE A, KAITHWAS G, VISEN P, SARAF S. Phytopharmacological screening of Luffa acutangula fruits for its antihepatotoxic activity. Ars Pharm [Internet]. 2007 Dec. 20 [cited 2024 Jul. 22];48(4):351-60. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4998

Issue

Vol. 48 No. 4 (2007)

Section

Original Articles

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