Physical characterization and dissolution properties of solid dispersions of the oxazepam with carbomer 934P
Keywords:
Solid dispersions, Oxazepam, Carbomer 934P, Dissolution studies, Infrared espectroscopy, X-ray diffractometry, Differential scanning calorimetryAbstract
The formulation of solid dispersions is an effective method of increasing the dissolution rate of poorly soluble drugs.The purpose of this study was to prepare and to characterize solid dispersions of oxazepam with carbomer 934P toimprove their dissolution properties. Solid dispersions were prepared by dissolution method and the dissolution rates ofsolid dispersions were compared with those ones of physical mixtures and pure drug. The evaluation of solid dispersionscharacteristics was performed using infrared espectroscopy (IR), X-ray diffractometry (X-R), differential scanning calorimetry(DSC) and dissolution assay. IR, X-R and DSC data showed no drug-polymer interaction. The results obtainedfrom dissolution studies showed that the dissolution rate of oxazepam was considerably better when it was formulatedin solid dispersions with carbomer 934P compared with those of physical mixtures and pure oxazepam.Downloads
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