Stability study of pharmaceutical suspensions for modifi ed morphine chlorohydrate release

Authors

  • Mª E MORALES Dpto. de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia. Granada Dirección para correspondencia: Mª E. Morales Hernández. Dpto de Farmacia y Tecnología Farmacéutica Facultad de Farmacia. Campus de Cartuja. Granada
  • G LÓPEZ Dpto. de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia. Granada Dirección para correspondencia: Mª E. Morales Hernández. Dpto de Farmacia y Tecnología Farmacéutica Facultad de Farmacia. Campus de Cartuja. Granada
  • Mª A RUIZ Dpto. de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia. Granada Dirección para correspondencia: Mª E. Morales Hernández. Dpto de Farmacia y Tecnología Farmacéutica Facultad de Farmacia. Campus de Cartuja. Granada

Keywords:

Released modified, Pharmaceutical suspensions, Morphine Chlorohydrate

Abstract

Chronic pain is a topic of major importance in modern medicine and is very costly both economically, as well as interms of human suffering. The opiates are clearly indicated for its treatment, with morphine being the most commonlyused prototype drug. Due to its convenience and high degree of acceptation, this drug is most frequently administeredorally. In the treatment of chronic pain, controlled release systems are currently considered as the most appropriate.The design of such systems involves the use of polymers as transport vehicles of the drug. Consequently, the aim of thisstudy was to prepare a colloidal suspension for oral use, using ethylcellulose pseudolatex as transport vehicle, in order toproduce a liquid microencapsulated morphine preparation for controlled release, suitable for persons presenting diffi cultyin swallowing and digestion, as in the case of children or the elderly. The design of an optimally stable formulation wasachieved, subsequent to several viscosity studies of varying nature carried out on different concentrations of Xanthamgum, carbopol and sodium carboxymethylcellulose and avicel. Additionally, exhaustive studies on rheological behaviourand sedimentation were carried out, in order to obtain a suspension that did not readily form sediments, could be easilyreconstructed through slight agitation, and presented suffi cient natural fl uidity from its package presentation.

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Published

2007-06-20

How to Cite

1.
MORALES ME, LÓPEZ G, RUIZ MA. Stability study of pharmaceutical suspensions for modifi ed morphine chlorohydrate release. Ars Pharm [Internet]. 2007 Jun. 20 [cited 2024 Jul. 22];48(2):157-73. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4983

Issue

Vol. 48 No. 2 (2007)

Section

Original Articles

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